文献类型：期刊文献

英文题名：Chemical reaction powered transient polymer hydrogels for controlled formation and free release of pharmaceutical crystals

作者：Bai, Shengyu[1];Niu, Xiaofeng[1];Wang, Hucheng[1];Wei, Lai[1];Liu, Liqun[1];Liu, Xinyu[1];Eelkema, Rienk[2];Guo, Xuhong[1];van Esch, Jan H.[2];Wang, Yiming[1]

机构：[1]East China Univ Sci & Technol, State Key Lab Chem Engn, Shanghai 200237, Peoples R China;[2]Delft Univ Technol, Dept Chem Engn, Maasweg 9, NL-2629 HZ Delft, Netherlands

年份：2021

卷号：414

外文期刊名：CHEMICAL ENGINEERING JOURNAL

收录：;EI(收录号：20210709934117);WOS:【SCI-EXPANDED(收录号:WOS:000641316500001)】；

基金：We thank Dr. X, Zhang for helpful discussion on the crystallization experiments. Y. Wang gratefully acknowledges NSFC Grants (21908061) , the Fundamental Research Funds for the Central Universities (JKA012016012) and the ECUST Innovation Program (SP2002A001) for financial support.

语种：英文

外文关键词：Transient materials; Hydrogels; Out-of-equilibrium systems; Pharmaceutical crystallization; Dynamic crosslinking

摘要：Transient materials that function out-of-equilibrium have been of great interest due to their unique properties that are rarely observed in thermodynamically stable occasions. However, the current advances are still limited to supramolecular objects, and the applications using this transient nature remain largely unexplored. Herein we report on chemical fuel powered transient polymer hydrogels for controlled formation and free release of pharmaceutical crystals. The transient polymer hydrogels with highly tunable stiffness and lifetime were created by chemical fuel powered crosslinking, which can be well regenerated without obvious deteriorations by simply refueling. On the basis of these properties, especially the transient nature, these hydrogels can serve as novel reusable platforms to control the pharmaceutical crystallization, more importantly, freely release the obtained crystals, which is inaccessible by conventional static gels. This work is expected to serve as an example to accelerate the development of more advanced out-of-equilibrium materials and exploitations of their high-tech applications.