文献类型：期刊文献

英文题名：Kinetically Controlled Preparation of Worm-like Micelles with Tunable Diameter/Length and Structural Stability

作者：Hou, Wangmeng[1];Yin, Xiuzhe[1];Zhou, Yingqing[1];Zhou, Zhuo[1];Liu, Zhijia[1];Du, Jianzhong[2,3];Shi, Yi[1];Chen, Yongming[1,4]

机构：[1]Sun Yat Sen Univ, Sch Mat Sci & Engn, Key Lab Polymer Composite & Funct Mat, Minist Educ, Guangzhou 510006, Peoples R China;[2]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China;[3]Tongji Univ, Sch Mat Sci & Engn, Dept Polymer Mat, Shanghai 201804, Peoples R China;[4]Henan Univ, Coll Chem & Mol Sci, Kaifeng 475004, Peoples R China

年份：2024

卷号：146

期号：34

起止页码：24094

外文期刊名：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

收录：;EI(收录号：20243416900328);WOS:【SCI-EXPANDED(收录号:WOS:001291820400001)】；

基金：The authors gratefully acknowledge the financial support from the National Natural Science Foundation of China (nos. 22071271, 22371313, 22305177, 21925505, and 22335005), the Natural Science Foundation of Guangdong Province (2024A1515011133 and 2021A1515110853), and the Fundamental Research Funds for the Central Universities (23yxqntd002).

语种：英文

外文关键词：Controlled drug delivery - Crosslinking - Kinetic parameters - Ring opening polymerization - Self assembly - Targeted drug delivery

摘要：Anisotropic nanoparticles such as worm-like micelles have aroused much attention due to their promising applications from templates to drug delivery. The fabrication of worm-like micelles with tunable structural stability and control over their diameter and length is of great importance but still challenging. Herein, we report a kinetically controlled ring-opening metathesis polymerization-induced self-assembly (ROMPISA) for the robust preparation of kinetically trapped worm-like micelles with tunable diameter/length at enlarged experimental windows by the rational manipulation of kinetic factors, including solvent property, temperature, and pi-pi stacking effects. The resultant worm structures were thermodynamically metastable and capable of excellent structural stability at room temperature due to the kinetic trapping effect. At elevated temperatures, these thermodynamically metastable worms could undergo morphology evolution into vesicular structures in a controlled manner. Moreover, the structural stability of worms could also be significantly enhanced by in situ cross-linking. Overall, this kinetically controlled ROMPISA opens a new avenue for PISA chemistry that is expected to prepare "smart" polymer materials by manipulating kinetic factors.