文献类型：期刊文献

英文题名：A highly selective and sensitive fluorescence "turn-on" probe for Ag⁺ in aqueous solution and live cells

作者：Xu, Lin[1];Xu, Yufang[1];Zhu, Weiping[1];Yang, Chunmei[1];Han, Le[1];Qian, Xuhong[1]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab Chem Biol, State Key Lab Bioreactor Engn, Sch Pharm, Shanghai 200237, Peoples R China

年份：2012

卷号：41

期号：24

起止页码：7212

外文期刊名：DALTON TRANSACTIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000304716800006)】；

基金：We are grateful for the financial support from National Basic Research Program of China (973 Program, 2010CB126100), the China 111 Project (Grant B07023), the Key New Drug Creation and Manufacturing Program (Grant 2009ZX09103-102) and the Shanghai Leading Academic Discipline Project (B507). We also thank Professor Youjun Yang of ECUST for discussions and suggestions.

语种：英文

摘要：A naphthalimide-based fluorescent probe, NPQ, that contains a novel receptor was successfully developed. NPQ exhibited "turn-on" fluorescence and excellent selectivity toward Ag+ in the presence of various other metal ions in aqueous solution. A series of control compounds were designed and synthesized in order to explore the photoinduced electron transfer (PET) quenching mechanism of NPQ and binding mode of NPQ with Ag+. Moreover, with the NPQ-Ag+ complex, I- was easily selectively recognized by a marked fluorescence quenching. The live cell imaging experiments demonstrate that NPQ can be used as a fluorescent probe for monitoring Ag+ in living cells.