文献类型：期刊文献

英文题名：Nucleophilic Addition-Electrophilic Coupling with a Carbanion Intermediate

作者：Song, X.[1]; Wang, W.[2,3]

机构：[1] University of New Mexico, Albuquerque, NM, United States; [2] Zhengzhou University, Zhengzhou, China; [3] East China University of Science and Technology, Shanghai, China

年份：2014

卷号：4

起止页码：86

外文期刊名：Comprehensive Organic Synthesis: Second Edition

收录：EI(收录号：20172603824651)

语种：英文

外文关键词：Addition reactions - Ketones - Catalysis - Unsaturated compounds - Arsenals

摘要：The strategy of nucleophilic addition-electrophilic couplings has become one of the central tenets and instruments in the arsenal of modern organic synthesis, since the discovery and development of novel catalytic systems and activation modes. In addition to traditional metal catalysis, organocatalysis has emerged as a new complementary tool, which has made significant achievements in the field. The broad selection of α,β-unsaturated compounds including α,β-unsaturated aldehydes, ketones, esters, amides, nitroolefins, and alkynals is presented, together with a variety of Michael donors and carbophilic electrophiles have been conceived and harvested for the efficient and stereoselective construction of complex molecular architectures, which usually possess at least two chiral centers. The approach can dramatically improve the synthetic efficiency in a fashion of the atom economy, and naturally falls into the category of a cascade reaction. ? 2014 Elsevier Ltd. All rights reserved.