文献类型：期刊文献

英文题名：Functionalization of small black phosphorus nanoparticles for targeted imaging and photothermal therapy of cancer

作者：Deng, Lijuan[1,2];Xu, Yifan[1,2];Sun, Caixia[2];Yun, Baofeng[3];Sun, Qiao[2];Zhao, Chongjun[1];Li, Zhen[2]

机构：[1]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai Key Lab Adv Polymer Mat, Key Lab Ultrafine Mat,Minist Educ, Shanghai 200237, Peoples R China;[2]Soochow Univ, Sch Radiol & Interdisciplinary Sci RAD X, Collaborat Innovat Ctr Radiat Med Jiangsu Higher, Ctr Mol Imaging & Nucl Med,State Key Lab Radiat M, Suzhou 215123, Peoples R China;[3]Soochow Univ, Coll Text & Clothing Engn, Suzhou 215123, Peoples R China

年份：2018

卷号：63

期号：14

起止页码：917

外文期刊名：SCIENCE BULLETIN

收录：;EI(收录号：20182505342767);WOS:【SCI-EXPANDED(收录号:WOS:000439778600008)】；

基金：Zhen Li acknowledges support from the National Natural Science Foundation of China (81471657, 81527901), the 1000 Plan for Young Talents, Jiangsu Specially Appointed Professorship, and Jiangsu Provincial Program for Innovative and Entrepreneurial Talents. The authors also are grateful for support from the Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection, the Priority Academic Development Program of Jiangsu Higher Education Institutions (PAPD). The authors would like to thank Dr. Tania Silver for critical reading of the manuscript.

语种：英文

外文关键词：Black phosphorus; Functionalization; Targeted imaging; Photothermal therapy

摘要：Black phosphorus (BP) nanomaterials have attracted extensive attention due to their unique physical, chemical, and biological properties. In this study, small BP nanoparticles were synthesized and modified with dextran and poly(ethyleneimine) for functionalization with folic acid and cyanine 7. The functionalized BP nanoparticles exhibit excellent biocompatibility, stability, and near infrared optical properties for targeted imaging of tumors through photoacoustic imaging and near-infrared fluorescence imaging. They also display high photothermal conversion efficiency for photothermal therapy of cancer. This work demonstrates the potential of functionalized small BP nanoparticles as an emerging nanotheranostic agent for the diagnosis and treatment of cancer. (C) 2018 Science China Press. Published by Elsevier B.V. and Science China Press. All rights reserved.