文献类型：期刊文献

英文题名：A Light-Driven Molecular Machine Controls K+ Channel Transport and Induces Cancer Cell Apoptosis

作者：Yang, Huiting[1,2];Yi, Jinhao[1,2];Pang, Shihao[1,2];Ye, Kai[1,2];Ye, Zhicheng[1,2];Duan, Qi[1,2];Yan, Zexin[1,2];Lian, Cheng[1,2];Yang, Yi[3];Zhu, Linyong[1,2,3];Qu, Da-Hui[1,2];Bao, Chunyan[1,2,3]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem,Key Lab Adv Mat, Frontiers Sci Ctr Materiobiol & Dynam Chem,Fering, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem,Joint Int Res Lab Precis Chem & Mo, Frontiers Sci Ctr Materiobiol & Dynam Chem,Fering, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Shanghai Frontier Sci Ctr Optogenet Tech Cell Met, Sch Pharm, Shanghai 200237, Peoples R China

年份：2022

卷号：61

期号：26

外文期刊名：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

收录：;EI(收录号：20221812069480);WOS:【SCI-EXPANDED(收录号:WOS:000790031800001)】；

基金：This work was supported by National Natural Science Foundation of China (grants 22025503, 22171085, 21871084), Shanghai Municipal Science and Technology Major Project (Grant 2018SHZDZX03), the Fundamental Research Funds for the Central Universities, the Program of Introducing Talents of Discipline to Universities (grant B16017), Program of Shanghai Academic/Technology Research Leader (19XD1421100), the Starry Night Science Fund of Zhejiang University Shanghai Institute for Advanced Study (grant SN-ZJU-SIAS-006), and Shanghai Frontier Science Center of Optogenetic Techniques for Cell Metabolism (grant 2021 Sci & Tech 03-28). The authors thank the Research Center of Analysis and Test of East China University of Science and Technology for help on the material characterization.

语种：英文

外文关键词：Apoptosis; Ion Channels; K+ Transport; Light-Triggered Rotation; Molecular Motor

摘要：The design of artificial ion channels with high activity, selectivity and gating function is challenging. Herein, we designed the light-driven motor molecule MC2, which provides new design criteria to overcome these challenges. MC2 forms a selective K+ channel through a single molecular transmembrane mechanism, and the light-driven rotary motion significantly accelerates ion transport, which endows the irradiated motor molecule with excellent cytotoxicity and cancer cell selectivity. Mechanistic studies reveal that the rotary motion of MC2 promotes K+ efflux, generates reactive oxygen species and eventually activates caspase-3-dependent apoptosis in cancer cells. Combined with the spatiotemporally controllable advantages of light, we believe this strategy can be exploited in the structural design and application of next-generation synthetic cation transporters for the treatment of cancer and other diseases.