文献类型：期刊文献

英文题名：Hyaluronic acid-based antibacterial hydrogels constructed by a hybrid crosslinking strategy for pacemaker pocket infection prevention

作者：Dong, Quanbin[1];Zhong, Xuepeng[2];Zhang, Yiqing[2];Bao, Bingkun[2];Liu, Liang[1];Bao, Huihui[1];Bao, Chunyan[2];Cheng, Xiaoshu[1];Zhu, Linyong[2];Lin, Qiuning[2]

机构：[1]Nanchang Univ, Dept Cardiol, Affiliated Hosp 2, 1 Minde Rd, Nanchang 330006, Jiangxi, Peoples R China;[2]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Optogenet & Synthet Biol Interdisciplinary Res Ct, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2020

卷号：245

外文期刊名：CARBOHYDRATE POLYMERS

收录：;EI(收录号：20202508838935);WOS:【SCI-EXPANDED(收录号:WOS:000552863700013)】；

基金：This work was supported by grants from the National Natural Science Foundation of China (13008958, 21774030 and 13007797) and "5511" Project Driven by Innovation in Jiangxi Province (G/Y1661#).

语种：英文

外文关键词：Hyaluronic acid; Chlorhexidine; Hybrid crosslinking; Antibacterial hydrogel; Cardiovascular implantable electronic device; Pocket infection

摘要：In this study, we developed an injectable antibacterial hydrogel based on hyaluronic acid (HA) and chlorhex-idine (CHX) for cardiovascular implantable electronic device (CIED) infection treatment. To balance stability and moldability, the HA scaffold was pre-crosslinked by 1,4-butanediol diglycidyl ether (BDDE) and then ground to form an HA microgel (CHA). Then, the antibacterial agent CHX was further crosslinked in the CHA microgel through electrostatic interactions between CHA and CHX to obtain hybrid crosslinked hydrogels (CHA/CHX). These hydrogels exhibited shear-thinning/self-recovery behavior, allowing easy injection into the CIED pocket and good matching with the pocket shape without extra space requirements, which represents an improvement on previously reported methods. In vitro and in vivo antibacterial tests showed that the CHA/CHX hydrogels had both good biocompatibility and very effective antibacterial action. The above results indicated that the CHA/CHX hydrogels would be an excellent candidate for CIED pocket infection treatment.