文献类型：期刊文献

英文题名：Abieseconordines A and B, two novel norditerpenoids with a 18-nor-5,10:9,10-disecoabietane skeleton from Abies Forrestii

作者：Yu, Ping[1]; Zhang, Shou-De[3]; Li, Yong-Li[3]; Yang, Xian-Wen[2]; Zeng, Hua-Wu[3]; Li, Hong-Lin[4]; Zhang, Wei-Dong[1,3]

机构：[1] Department of Natural Product Chemistry, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China; [2] Key Laboratory of Marine Bio-resources Sustainable Utilization, RNAM Center for Marine Microbes, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China; [3] School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China; [4] Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China

年份：2012

卷号：95

期号：3

起止页码：415

外文期刊名：Helvetica Chimica Acta

收录：EI(收录号：20121414914897)

语种：英文

外文关键词：Molecular orbitals - Bioassay - Dichroism - Musculoskeletal system - Nitric oxide - Spectroscopic analysis - Nuclear magnetic resonance spectroscopy

摘要：A systematic phytochemical investigation on Abies forrestii afforded two new and 20 known compounds. Abieseconordines A and B (1 and 2) are the first two examples of norditerpenes with a novel 18-nor-5,10:9,10-disecoabietane skeleton. Their structures were established mainly by analysis of 1D- and 2D-NMR spectroscopic data. In addition, electronic circular-dichroism calculations and molecular-orbital analysis were utilized to confirm the absolute configuration of 1. Both compounds exhibited a potent effect in a bioassay inhibiting LPS-stimulated NO production in RAW264.7 macrophages. Copyright ? 2012 Verlag Helvetica Chimica Acta AG, Zürich, Switzerland.