文献类型：期刊文献

英文题名：Fabrication of graphene oxide-modified chitosan for controlled release of dexamethasone phosphate

作者：Sun, Huanghui[1];Zhang, Lingfan[2];Xia, Wei[1];Chen, Linxiao[1];Xu, Zhizhen[1];Zhang, Wenqing[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai, Peoples R China;[2]East China Univ Sci & Technol, Res Ctr Anal & Test, Shanghai 200237, Peoples R China

年份：2016

卷号：122

期号：7

外文期刊名：APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING

收录：;EI(收录号：20162602543628);WOS:【SCI-EXPANDED(收录号:WOS:000379002100003)】；

基金：We are grateful for the financial support by the Leading Personnel Plan of Shandong Province (tsls 20150214), National Natural Science Foundation of China (Grant No. 21407050), the Fundamental Research Funds for the Central Universities (Grant No. 22A201514019) and Yunnan cooperation academician workstation.

语种：英文

外文关键词：Targeted drug delivery - Controlled drug delivery - Drug products - Graphene - Nanocomposites - Hydrophobicity - Biocompatibility - Chemical bonds

摘要：Functionalized graphene oxide with its unique physical and chemical properties is widely applied in bio-materials, especially in drug carrier materials. In the past few years, a number of different drugs have been loaded on functionalized graphene oxide via pi-pi stacking and hydrophobic interactions. The present report described a new approach, dexamethasone phosphate successfully loaded onto graphene oxide-chitosan nanocomposites as drug carrier materials by covalent bonding of phosphate ester linkage. Compared with the graphene oxide-chitosan nanocomposites that dexamethasone phosphate was loaded on via simple physical attachment, covalently linked composites as drug carrier materials were more biocompatible which effectively reduced the burst release of drug, and controlled the release of drug in different pH conditions.