文献类型：期刊文献

英文题名：Practical Cu(OAc)2/TEMPO-catalyzed selective aerobic alcohol oxidation under ambient conditions in aqueous acetonitrile

作者：Jiang, Jian-An[1];Du, Jia-Lei[1];Wang, Zhan-Guo[2];Zhang, Zhong-Nan[1];Xu, Xi[1];Zheng, Gan-Lin[1];Ji, Ya-Fei[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[2]Roche R&D Ctr China Ltd, Shanghai 201203, Peoples R China

年份：2014

卷号：55

期号：10

起止页码：1677

外文期刊名：TETRAHEDRON LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000332803800001)，CCR-EXPANDED(收录号:WOS:000332803800001)】；

基金：The authors are grateful to the National Natural Science Foundation of China (Project No. 21176074) for financial support.

语种：英文

外文关键词：Aerobic alcohol oxidation; Ambient conditions; Copper(II) acetate; TEMPO; Formation of carbonyl group

摘要：We reported a ligand- and additive-free Cu(OAc)(2)/TEMPO catalyst system that enables efficient and selective aerobic oxidation of a broad range of primary and secondary benzylic alcohols, primary and secondary 1-heteroaryl alcohols, cinnamyl alcohols, and aliphatic alcohols to the corresponding aldehydes and ketones. This ambient temperature oxidation protocol is of practical features like aqueous acetonitrile as solvent, ambient air as the terminal oxidant, and low catalyst loading, presenting a potential value in terms of both economical and environmental considerations. Based on the experimental observations, a plausible reaction mechanism was proposed. (C) 2013 Elsevier Ltd. All rights reserved.