文献类型：期刊文献

中文题名：精油恢复嗅觉功能障碍的研究进展

英文题名：Research progress of essential oils in restoring olfactory dysfunction

作者：王希奥[1];周露露[1];胡静[2]

机构：[1]上海应用技术大学香料香精化妆品学部,上海201418;[2]华东理工大学化工学院,上海200237

年份：2025

卷号：42

期号：11

起止页码：2407

中文期刊名：精细化工

外文期刊名：Fine Chemicals

收录：;EI(收录号：20260119858888);北大核心:【北大核心2023】；

基金：国家自然科学基金项目(22078196、22278268);上海市自然科学基金项目(22ZR1460400);上海市青年科技英才扬帆计划资助项目(23YF1446300);上海应用技术大学引进人才科研启动项目(YJ2023-10)。

语种：中文

中文关键词：精油;嗅觉功能障碍;COVID-19;鼻炎;神经退行性疾病;研究进展

外文关键词：essential oils;olfactory dysfunction;COVID-19;rhinitis;neurodegenerative diseases;research progress

摘要：全球范围内,新型冠状病毒(COVID-19)大流行引发了嗅觉功能障碍病例的急剧增加。目前,对于嗅觉功能障碍的治疗面临多重挑战,包括缺乏统一的治疗标准、类固醇等药物长期使用存在耐药性风险、鼻内镜手术带来的不可逆损伤等。而精油及其挥发性成分具有抗炎、抗病毒等生物活性,有助于嗅觉功能的恢复。此外,精油的特殊活性还能够进一步增强嗅觉神经的再生能力。该文对气味感知机制与嗅觉功能障碍的临床病因进行了总结:COVID-19、神经退行性疾病和鼻炎介导嗅觉功能障碍的机制主要包括病毒感染、炎症和乙酰胆碱酯酶过度活跃,在此基础上,从不同生物活性的视角深入探讨了精油治疗嗅觉功能障碍的可能性,并从精油递送方面详细讨论其临床应用前景,旨在为嗅觉功能障碍治疗领域提供清晰深入的见解。
Globally,Corona Virus Disease 2019(COVID-19)pandemics have triggered a dramatic increase in cases of olfactory dysfunction.At present,the treatment of olfactory dysfunction faces multiple challenges,including the lack of uniform treatment standards,the risk of drug resistance to long-term use of steroids and other drugs,and irreversible damage caused by endoscopic sinus surgery.Essential oils and their volatile components have anti-inflammatory,antiviral and other biological activities,which are conducive to the recovery of olfactory function.In addition,the special activity of essential oils can further enhance the regeneration ability of the olfactory nerve.In this review,the mechanisms of odor perception and the clinical etiology of olfactory dysfunction were summarized,with the mechanisms of olfactory dysfunction in COVID-19,neurodegenerative diseases and rhinitis mainly attributed to viral infection,inflammation and acetylcholinesterase hyperactivity.On this basis,the potential of essential oils in the treatment of olfactory dysfunction was explored in terms of different biological activities,and its clinical application prospects were discussed in detail from the perspective of essential oils delivery,aiming to provide clear and in-depth insights in the field of olfactory dysfunction treatment.