文献类型：期刊文献

英文题名：Precise phase adjustment and antibacterial property of copper sulfide particles in confined mesoporous silica nanoreactor

作者：Xu, Shiyu[1];Wu, Jinyong[1];Ren, Zhongzhen[1];Niu, Dechao[1]

机构：[1]East China Univ Sci & Technol, Frontier Sci Ctr Mat Biol & Dynam Chem, Shanghai Engn Res Ctr Hierarch Nanomat, Sch Mat Sci & Engn,Low Dimens Mat Chem Lab,Key Lab, Shanghai 200237, Peoples R China

年份：2024

卷号：85

起止页码：113

外文期刊名：PARTICUOLOGY

收录：;EI(收录号：20231714005787);WOS:【SCI-EXPANDED(收录号:WOS:000988646600001)】；

基金：This work was financially supported by the National Natural Science Foundation of China (grant No. 52072124 and 51972112), Natural Science Foundation of Shanghai (grant No. 20ZR1414900), Program of Shanghai Academic/Technology Research Leader (grant No. 22XD1421100), The Fundamental Research Funds for the Central Universities, and the 111 project (grant No. B14018).

语种：英文

外文关键词：Copper sulfides; Mesoporous silica; Photothermal; Reactive oxygen species; Antibacterial agent

摘要：Bacteria-caused wound infection greatly threatens human health, thus developing an efficient and safe antibacterial agent without drug resistance is still a great challenge. Herein, a confined vulcanization strategy is proposed to construct copper sulfides-loaded dual-mesoporous silica nanospheres (Cux-Sy@DMSNs) with various crystal phases for reactive oxygen species (ROS)-mediated and photothermal antibacterial application. With the pore confinement of DMSNs, the crystal phases of copper sulfides including CuS, Cu9S5 and Cu1.96S can be easily controlled by changing the vulcanization temperature. The relationships between the crystal phases and photothermal properties as well as peroxidase-like activity of copper sulfides were systematically investigated. Results show that the obtained CuS@DMSNs exhibited higher photothermal ability with remarkable photothermal conversion efficiency of 36.86% in the second near-infrared region (NIR-II) and better peroxidase-like activity, compared to those of Cu9S5@DMSNs and Cu1.96S@DMSNs. As a result, the in vitro experiments showed the good antibacterial effect against both gram-negative E. coli and gram-positive S. aureus under 1064 nm laser irradiation and the presence of H2O2. Besides, the CCK-8 assay indicated that CuS@p-DMSNs have minimal cytotoxicity against normal human umbilical vein endothelial cells at the ranged concentrations. Therefore, the resultant CuS@p-DMSNs could act as a promising antibacterial agent for deep wound bacterial infection treatment.(c) 2023 Chinese Society of Particuology and Institute of Process Engineering, Chinese Academy of Sciences. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).