文献类型：期刊文献

英文题名：Highly Diastereo- and Enantioselective Cross-Cascade Reactions of Different Enones

作者：Huang, Huicai[1];Wu, Wenbin[1];Zhu, Kailong[1];Hu, Juan[1];Ye, Jinxing[1]

机构：[1]E China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Minist Educ, Sch Pharm, Shanghai 200237, Peoples R China

年份：2013

卷号：19

期号：12

起止页码：3838

外文期刊名：CHEMISTRY-A EUROPEAN JOURNAL

收录：;EI(收录号：20131216130857);WOS:【SCI-EXPANDED(收录号:WOS:000316009800009)，CCR-EXPANDED(收录号:WOS:000316009800009)】；

基金：The authors thank the National Natural Science Foundation of China (20902018, 21272068), Innovation Program of Shanghai Municipal Education Commission (11ZZ56), the Fundamental Research Funds for the Central Universities, and 111 project (B07023) for the financial support of this project.

语种：英文

外文关键词：amines; asymmetric synthesis; cross-cascade reactions; cyclohexanones; enones

摘要：Cascading ketones! The first highly efficient asymmetric cross-cascade reaction of different α,β-unsaturated ketones catalyzed by an easily prepared bulky primary amine salt has been developed. It affords the corresponding diverse products containing three to four contiguous stereocenters with excellent enantio- and diastereoselectivities (see scheme). Copyright ? 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.