文献类型：专利

英文题名：New hydrophilic chromatographic filler having mixed ion exchange mode useful in chromatographic mode based hydrophilic chromatography and selective enrichment of glycopeptides or phosphorylated peptides in modified proteomics

作者：SHENG Q;LAN M;CHEN M;XIONG Y;XUE C;DONG L;CHEN Y

机构：[1]UNIV EAST CHINA SCI & TECHNOLOGY

申请号：CN107138144-A

申请日：2017-05-25

公开日：2017-09-08

语种：英文

收录：DERWENT

摘要：NOVELTY - Hydrophilic chromatographic filler having mixed ion exchange mode (I) are new. USE - (I) are useful in chromatographic mode based hydrophilic chromatography or ion chromatographic separation and selective enrichment of glycopeptides or phosphorylated peptides in modified proteomics (claimed). ADVANTAGE - (I) controls and optimize ion exchange capacity. The preparation method has excellent controllability, repeatability and stability. DETAILED DESCRIPTION - Hydrophilic chromatographic filler having mixed ion exchange mode of formula (I) are new. dotted line = silica Gel i.e. spherical silica gel which is zygotic ion bonded phase with terminal group; n = 0-4; X = positively charged functional group including amino and quaternary ammonium groups; and Y1 = negatively charged functional group including carboxy group and sulfonic acid group. An INDEPENDENT CLAIM is also included for preparation of (I).