文献类型：期刊文献

英文题名：Sensitive magnetic solid-phase microextraction based on oxide multi-walled carbon-nanotubes for the determination of methylamphetamine and ketamine in human urine and blood

作者：Zhang, Suling[1];Cui, Yanhua[2];Sun, Jiancong[2];Xi, Yongqing[3];Zhang, Chunxiao[1];Tang, Junhong[1]

机构：[1]Hangzhou Dianzi Univ, Coll Mat & Environm Engn, Hangzhou 310018, Zhejiang, Peoples R China;[2]Publ Secur Bur Huzhou, Huzhou 313000, Peoples R China;[3]E China Univ Sci & Technol, Res Ctr Anal & Test, Shanghai 200237, Peoples R China

年份：2015

卷号：7

期号：10

起止页码：4209

外文期刊名：ANALYTICAL METHODS

收录：;EI(收录号：20152100862111);WOS:【SCI-EXPANDED(收录号:WOS:000354489500023)】；

基金：This work was supported by the Zhejiang Provincial Natural Science Foundation of China (LQ13B050005), the National Natural Science Foundation of China (21305026, 41373121), the Scientific Research Fund of Zhejiang Provincial Education Department (Y201327380), and the Scientific Research Foundation of Hangzhou Dianzi University (KYS205612034).

语种：英文

外文关键词：Amines - Drug products - Hydrogen bonds - Blood - Curve fitting - Ionic strength - Multiwalled carbon nanotubes (MWCN) - Patient monitoring - Mass spectrometry - Solvent extraction - Yarn

摘要：A sensitive and rapid magnetic solid-phase microextraction (MSPE) procedure based on multi-walled carbon nanotubes (MWNTs), combined with gas chromatography-mass spectrometry (GC-MS), was developed for the quantification of two illegal basic drugs, methamphetamine (MA) and ketamine (KT), in human urine and whole-blood samples. Acid-oxidized MWNTs (o-MWNTs), selected as the adsorbent, have good affinity to these two drugs due to the pi-pi stacking interactions derived from the aromatic rings, and to the hydrogen bonds provided by the chelation sites of oxygen-containing functional groups on their surfaces. Ionic strength, pH level, desorption solvent and extraction time were optimized in sequence to yield the highest signal response for the two drugs. Under optimized conditions, the calibration curves were linear over the range of 0.2-50 ng mL(-1) with R-2 higher than 0.99, and resulted in good precision (6.8-7.1% for intra-day, 7.4-9.2% for inter-day). The limits of detection for MA and KT were 0.044 and 0.024 ng mL(-1), respectively, which were below the cut-off values recommended by the United Nations Office on Drugs and Crime (UNODC), and were lower than those of other reported analytical methods. The application feasibility of the method in illegal drug monitoring was demonstrated by analyzing the urine and blood samples collected from a nonuser volunteer and a suspected drug abuser in a forensic case, respectively. Solvent extraction for protein precipitation before the MSPE procedure involved here was confirmed to improve the recoveries in dealing with biological samples. This method is simple, sensitive, and provides an accurate and sensitive detection platform for drug abuse analysis.