文献类型：期刊文献

英文题名：Titanium(IV) Chloride-Mediated Stereoselective -Alkylidenation to Efficiently Assemble Multisubstituted 1,3-Dienes

作者：Sun, Rengwei[1];Song, Wei[1];Ma, Chunmei[1];Zhang, Huiwen[1];Yu, Xinhong[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China

年份：2016

卷号：358

期号：24

起止页码：3977

外文期刊名：ADVANCED SYNTHESIS & CATALYSIS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000391810000010)，CCR-EXPANDED(收录号:WOS:000391810000010)】；

基金：This work was financially supported by National Natural Science Foundation of China (No. 21476078) and Science and Technology Commission of Shanghai Municipality (No. 12431900902).

语种：英文

外文关键词：alkylidenation; conjugated dienes; regioselectivity; titanium(iv) chloride; vinylogous aldol condensation

摘要：A direct access to multisubstituted 1,3-dienes by -exclusive alkylidenation of crotonic derivatives has been developed. This protocol, mediated by titanium tetrachloride chelation, features excellent regio- and stereoselectivity, mild reaction conditions, easy operation and wide substrate scope. Conversions of the derived dienes to other useful molecules were also explored.