文献类型：期刊文献

英文题名：Annual trends and health risks of antibiotics and antibiotic resistance genes in a drinking water source in East China

作者：Hu, Yaru[1,2,3];Jin, Lei[4];Zhao, Yi[5];Jiang, Lei[4];Yao, Shijie[1,2];Zhou, Wang[1,2];Lin, Kuangfei[1,3];Cui, Changzheng[1,2,3]

机构：[1]East China Univ Sci & Technol, Sch Resources & Environm Engn, State Environm Protect Key Lab Environm Risk Asse, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Shanghai Environm Protect Key Lab Environm Standa, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Natl Engn Lab Ind Wastewater Treatment, Shanghai 200237, Peoples R China;[4]Natl Engn Res Ctr Urban Water Resources, Shanghai 200082, Peoples R China;[5]Pudong New Area Hydrol & Water Sources Adm Shangh, Shanghai 200000, Peoples R China

年份：2021

卷号：791

外文期刊名：SCIENCE OF THE TOTAL ENVIRONMENT

收录：;EI(收录号：20212510529558);WOS:【SCI-EXPANDED(收录号:WOS:000686012800011)】；

基金：This research was supported by the Science and Technology Commission of Shanghai Municipality (No. 20dz1200800), National Water Pollution Control and Management Technology Major Projects (No. 2017ZX07402003) and Shanghai Sailing Program (No. 21YF1409700).

语种：英文

外文关键词：Antibiotics; Antibiotic resistance genes (ARGs); Drinking water source; Successive monitoring; Annual increase

摘要：The extensive pollution of antibiotics and antibiotic resistance genes (ARGs) in drinking water has aroused worldwide concern. Successive monitoring of these pollutants has noteworthy significance for drinking water safety. Accordingly, this study conducted successive monitoring of antibiotics and ARGs from 2015 to 2017 in a drinking water source in East China. The total antibiotic concentration ranged from 19.68 ng/L to 497.00 ng/L, and decreased slightly from 2015 to 2017. Eighteen out of forty-one ARG subtypes showing resistance to six antibiotic classes and one class I integrase gene intI1, were detected in the drinking water source at concentrations ranging from 6.5 x 10(4) copies/mL to 1.6 x 10(6) copies/mL. Importantly, the total ARG concentration increased on an annual basis from 2015 to 2017 with an average annual increment of 0.25 orders of magnitude, which was mainly attributed to the increase in specific ARG subtypes, such as sul1, sul2, sul3, tetA, qnrB, and ermB. Most ARGs was positively correlated with the intI1 genes (r = 0.47-0.55, P < 0.01). Furthermore, the variation of antibiotics and ARGs appeared to be related to the water indices, particularly of the values of COD, BOD5, NO2-N (P < 0.05). This study provides basic data on antibiotic and ARG pollution in the studied drinking water source. Importantly, the findings expound that although the residual antibiotics in this drinking water source decreased slightly from 2015 to 2017, while its biological effect, the antibiotic resistance, increased annually, which give a warning of the antibiotic resistance pollution in the drinking water source. (C) 2021 Elsevier B.V. All rights reserved.