文献类型：期刊文献

英文题名：Harnessing 4D Printing Bioscaffolds for Advanced Orthopedics

作者：Chen, Xi[1];Han, Shuyan[2];Wu, Weihui[1];Wu, Zihan[1];Yuan, Yuan[1];Wu, Jun[2];Liu, Changsheng[1]

机构：[1]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Engn Res Ctr Biomat, Key Lab Ultrafine Mat,Minist Educ, Shanghai 200237, Peoples R China;[2]Sun Yat Sen Univ, Sch Biomed Engn, Key Lab Sensing Technol & Biomed Instrument Guang, Guangzhou 510006, Peoples R China

年份：2022

卷号：18

期号：36

外文期刊名：SMALL

收录：;EI(收录号：20220411515136);WOS:【SCI-EXPANDED(收录号:WOS:000744775800001)】；

基金：X.C. and S.H. contributed equally to this work. This work was primarily leveraged by National Natural Science Foundation of China (No. 51621002, 3210100616, 32101151, 51973243, and 52173150). Any opinions, findings, conclusions, or recommendations expressed herein are those of the author(s).

语种：英文

外文关键词：bioprinting; bone regeneration; scaffolds; shape-memory materials; tissue engineering

摘要：The development of programmable functional biomaterials makes 4D printing add a new dimension, time (t), based on 3D structures (x, y, z), therefore, 4D printed constructs could transform their morphology or function over time in response to environmental stimuli. Nowadays, highly efficient bone defect repair remains challenging in clinics. Combining programmable biomaterials, living cells, and bioactive factors, 4D bioprinting provides greater potential for constructing dynamic, personalized, and precise bone tissue engineering scaffolds by complex structure formation and functional maturation. Therefore, 4D bioprinting has been regarded as the next generation of bone repair technology. This review focuses on 4D printing and its advantages in orthopedics. The applications of different smart biomaterials and 4D printing strategies are briefly introduced. Furthermore, one summarizes the recent advancements of 4D printing in bone tissue engineering, uncovering the addressed and unaddressed medical requirements. In addition, current challenges and future perspectives are further discussed, which will offer more inspiration about the clinical transformation of this emerging 4D bioprinting technology in bone regeneration.