文献类型：期刊文献

英文题名：A novel strategy for tumor therapy: targeted, PAA-functionalized nano-hydroxyapatite nanomedicine

作者：Zhang, Shuiquan[1,2,3];Ma, Xiaoyu[1,2,3];Sha, Dongyong[1,2,3];Qian, Jiangchao[4];Yuan, Yuan[1,2,3];Liu, Changsheng[1,2,3]

机构：[1]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Engn Res Ctr Biomed Mat, Minist Educ, Shanghai 200237, Peoples R China;[4]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2020

卷号：8

期号：41

起止页码：9589

外文期刊名：JOURNAL OF MATERIALS CHEMISTRY B

收录：;EI(收录号：20204509452442);WOS:【SCI-EXPANDED(收录号:WOS:000582937800014)】；

基金：The authors wish to express their gratitude for the financial supports from the National Natural Science Foundation of China for Innovative Research Groups (No. 51621002), National Natural Science Foundation of China (No. 31871011, 31771040), and Leading Talents in Shanghai in 2017.

语种：英文

外文关键词：Cells - Medical nanotechnology - Hydroxyapatite - Nanocomposites - Tumors - Cytology - Organic acids - Diseases

摘要：The rapid development of nanotechnology has provided new strategies for the treatment of tumors. Nano-scale hydroxyapatite (HAP), as the main component of hard tissues in humans and vertebrates, have been found to specifically inhibit tumor cells. However, achieving controllable synthesis of HAP and endowing it with cancer cell-targeting properties remain enormous challenges. To solve this problem, we developed polyacrylic acid-coordinated hydroxyapatite nanoparticles (HAP-PAA) and further chemically grafted them with folic acid (HAP-PAA-FA) for cancer treatment in this study. The nucleation sites and steric hindrance provided by the PAA greatly inhibited the agglomeration of the nanoparticles, and at the same time, the excess functional groups further modified the surface of nanoparticles to achieve targeting efficiency. The spherical, low-crystallinity HAP-PAA nanoparticles exhibited good tumor cell lethality. After grafting the nanoparticles with folic acid for molecular targeting, their cellular uptake and specific killing ability of tumor cells were further enhanced. The HAP-PAA-FA nanoparticle system exerted a regulatory effect on the tumor microenvironment and had good biological safety. All the above results indicate that this research will broaden the application of hydroxyapatite in tumor treatment.