文献类型：期刊文献

英文题名：Solubility Measurements of Finerenone in Ten Monosolvents and Two Binary Solvent Mixtures

作者：Lin, Jia[1];Wu, Yanfang[1];Chang, Shengyuan[1];Liu, Yan[1]

机构：[1]East China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Sch Pharm, Minist Educ, Shanghai 200237, Peoples R China

年份：2025

卷号：70

期号：3

起止页码：1527

外文期刊名：JOURNAL OF CHEMICAL AND ENGINEERING DATA

收录：;EI(收录号：20251018008866);WOS:【SCI-EXPANDED(收录号:WOS:001437035800001)】；

语种：英文

外文关键词：Binary mixtures - Methanol

摘要：The solubility of finerenone, a third-generation nonsteroidal mineralocorticoid receptor antagonist drug, was measured in 10 monosolvents (methanol, ethanol, isopropanol, methyl acetate, ethyl acetate, isopropyl acetate, acetone, 2-butanone, acetonitrile, and dichloromethane) and two binary solvent mixtures (methanol + water and acetonitrile + water). Measurements were conducted at temperatures ranging from 273.15 to 313.15 K using PAT tools. In the methanol + water system, water acted solely as an antisolvent. However, in the acetonitrile + water system, finerenone's solubility exceeded its solubility in pure acetonitrile, reaching a maximum at a water mass fraction of approximately 0.2. To expand the applicability of the results, the experimental solubility data was correlated with the modified Apelblat model, the lambda h model, and the CNIBS/R-K model. The relative average deviation and root-mean-square deviation values indicate that the correlation results align well with the experimental data, and the modified Apelblat model proved the most suitable.