文献类型：期刊文献

英文题名：Extending the concentration limit of electrodialytic eluent generator for ion chromatography

作者：Chen, Weiqing[1];Jin, Huiling[1];Qin, Cheng[1];Zhang, Feifang[1];Yang, Bingcheng[1]

机构：[1]East China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Shanghai Frontiers Sci Ctr Optogenet Tech Cell Met, State Key Lab Bioreactor Engn,Sch Pharm, Shanghai 200237, Peoples R China

年份：2027

卷号：312

外文期刊名：TALANTA

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001836317500001)】；

基金：This work was sponsored by National Natural Science Foundation of China (No. 22374046) . It also thanks for the support from the Funda-mental Research Funds for the Central Universities.

语种：英文

外文关键词：Ion chromatography; Electrodialytic eluent generator; Dual-membrane; Single-membrane; Concentration limit; Gas-free

摘要：Electrodialytic eluent generators (EEGs) are established devices for producing high-purity base or acid eluents for ion chromatography (IC). Most commercial EEGs recommend a maximum output concentration of 100 mu eq/min. Here we investigate the concentration limits and key constraints. To this end, single-membrane (SM) and dual-membrane (DM) EEGs (6.2 cm(2)membrane area) were fabricated. The SM-EEG achieved similar to 180 mu eq/min at 16 MPa backpressure and similar to 300 mu eq/min without backpressure, with the difference attributed to accumulated gas bubbles in the eluent. A degasser limited useable output to 100 mu eq/min in suppressed IC, and higher concentrations required reduced flow rates (e.g., 160 mM at 0.05 mL/min). The DM-EEG reached similar to 510 mu eq/min without backpressure and similar to 300 mu eq/min at 16 MPa, with gas-free eluent enabling broader operation. Further increases are limited by membrane current density and gas accumulation in donor chambers. Nevertheless, the concentration range of DM-EEG under typical IC backpressure can be readily doubled (up to similar to 600 mu eq/min) through simple tandem DM cartridges, which adequately meets the demand for high-concentration eluents in sugar analysis (e.g., 480 mM KOH).