文献类型：期刊文献

中文题名：Recent developments in multimodality fluorescence imaging probes

英文题名：Recent developments in multimodality fluorescence imaging probes

作者：Jianhong Zhao[1];Junwei Chen[1];Shengnan Ma[1];Qianqian Liu[1];Lixian Huang[1];Xiani Chen[1];Kaiyan Lou[1];Wei Wang[1,2]

机构：[1]Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, and State Key Laboratory of Bioengineering Reactor, East China University of Science and Technology;[2]Department of Chemistry and Chemical Biology, University of New Mexico

年份：2018

卷号：8

期号：3

起止页码：320

中文期刊名：Acta Pharmaceutica Sinica B

外文期刊名：药学学报（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2017_2018】；PubMed;

基金：supported by the National Science Foundation of China(No.21577037 to Kaiyan Lou);East China University of Science and Technology(Grant No.YC0140101,start-up funds to Wei Wang)

语种：英文

中文关键词：Optical imaging;Fluorescence;Multimodality;Near-infrared fluorescence;Nanoprobe;Computed tomography;Magnetic resonance imaging;Positron emission tomo graphy;Single-photon emission computed tomography;Photoacoustic imaging

外文关键词：Optical imaging;Fluorescence;Multimodality;Near-infrared fluorescence;Nanoprobe;Computed tomography;Magnetic resonance imaging;Positron emission tomo graphy;Single-photon emission computed tomography;Photoacoustic imaging

摘要：Multimodality optical imaging probes have emerged as powerful tools that improve detection sensitivity and accuracy, important in disease diagnosis and treatment. In this review, we focus on recent developments of optical fluorescence imaging(OFI) probe integration with other imaging modalities such as X-ray computed tomography(CT), magnetic resonance imaging(MRI), positron emission tomography(PET), single-photon emission computed tomography(SPECT), and photoacoustic imaging(PAI). The imaging technologies are briefly described in order to introduce the strengths and limitations of each techniques and the need for further multimodality optical imaging probe development. The emphasis of this account is placed on how design strategies are currently implemented to afford physicochemically and biologically compatible multimodality optical fluorescence imaging probes. We also present studies that overcame intrinsic disadvantages of each imaging technique by multimodality approach with improved detection sensitivity and accuracy.
Multimodality optical imaging probes have emerged as powerful tools that improve detection sensitivity and accuracy, important in disease diagnosis and treatment. In this review, we focus on recent developments of optical fluorescence imaging(OFI) probe integration with other imaging modalities such as X-ray computed tomography(CT), magnetic resonance imaging(MRI), positron emission tomography(PET), single-photon emission computed tomography(SPECT), and photoacoustic imaging(PAI). The imaging technologies are briefly described in order to introduce the strengths and limitations of each techniques and the need for further multimodality optical imaging probe development. The emphasis of this account is placed on how design strategies are currently implemented to afford physicochemically and biologically compatible multimodality optical fluorescence imaging probes. We also present studies that overcame intrinsic disadvantages of each imaging technique by multimodality approach with improved detection sensitivity and accuracy.