文献类型：期刊文献

英文题名：Novel N,O-Cu(OAc)2 complex catalysed diastereo- and enantioselective 1,4-addition of glycine derivatives to alkylidene malonates

作者：Wang, Ming[1]; Shi, Yu-Hua[1]; Luo, Jun-Fei[1]; Du, Wenting[1]; Shi, Xiao-Xin[1]; Fossey, John S.[1,2]; Deng, Wei-Ping[1]

机构：[1] School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China; [2] School of Chemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom

年份：2011

卷号：1

期号：1

起止页码：100

外文期刊名：Catalysis Science and Technology

收录：EI(收录号：20111313873764)

语种：英文

外文关键词：Enantioselectivity

摘要：Newly developed chiral N,O-Cu(OAc)2 complexes were found to catalyse the diastereo- and enantioselective 1,4-addition of glycine derivatives to alkylidene malonates to afford 3-aryl glutamic acids derivatives in good yields (82-98%) and high stereoselectivities (up to 83% for anti and 90% for syn adducts, respectively). High optical purity anti adducts (up to 99% ee) can be obtained after simple recrystallisation, and their conversion to free 3-aryl glutamic acids was demonstrated by a representative example, chlorpheg, via a one pot process in 72% yield. ? 2011 The Royal Society of Chemistry.