文献类型：期刊文献

中文题名：特定结构的卟啉聚合物的构建及应用

英文题名：Construction and Applications of Well-defined Porphyrin-containing Polymers

作者：田佳[1];张伟安[1]

机构：[1]华东理工大学化学与分子工程学院上海市功能性材料化学重点实验室

年份：2019

卷号：50

期号：7

起止页码：653

中文期刊名：高分子学报

外文期刊名：Acta Polymerica Sinica

收录：CSTPCD;;Scopus;WOS:【SCI-EXPANDED(收录号:WOS:000485666300001)】；北大核心:【北大核心2017】；CSCD:【CSCD2019_2020】；

基金：国家自然科学基金(基金号51803058,21875063,21574039)资助项目

语种：中文

中文关键词：嵌段聚合物;卟啉;星型聚合物;超分子聚合物;光动力疗法

外文关键词：Block copolymer;Porphyrin;Star polymer;Supramolecular polymer;Photodynamic therapy

摘要：卟啉及其衍生物由于其独特的性质和功能而备受关注,并广泛应用于能源、催化和生物医学等领域.卟啉聚合物同时具有卟啉和聚合物的特征,在高分子领域引起了广泛关注.以卟啉为基元构建的特定结构卟啉聚合物不仅具有明确的分子结构,而且在性能上具有很多崭新的特点.通过将卟啉基元修饰成单体、引发剂和链转移试剂等功能基元,利用'点击化学'、原子转移自由基聚合和可逆加成-断裂链转移聚合等合成手段,许多具有特定结构的卟啉聚合物可以被高效可控地构建.本文主要介绍近几年包括本课题组在内的以卟啉为基元的嵌段聚合物、交替共聚物、星型聚合物以及树枝状聚合物等特定结构卟啉聚合物的构建,此类聚合物的结构和性能之间的构效关系以及其在光动力治疗等领域的应用.
Porphyrins and their derivatives have attracted much attention due to their unique properties and various functions,and have been widely used in energy,catalysis and biomedical fields.Porphyrin-containing polymers possess both porphyrin and polymeric characteristics,which have also aroused great interest.On the basis of functional porphyrin units,the well-defined porphyrin-containing polymers not only have a clear and specific macromolecular structure,but also have been endowed with a variety of novel and unique features.By modifying the porphyrin units into the initiators,monomers or chain transfer agents,well-defined functional porphyrin-containing polymers with specific structures could be efficiently constructed by ring-opening polymerization(ROP),atom transfer radical polymerization(ATRP),reversible addition-fragmentation chain transfer(RAFT)polymerization or the combination of other strategies such as click chemistry.These well-defined porphyrin-containing polymers including telechelic polymers,alternating copolymers,block copolymers,star polymers,supramolecular polymers,can self-assemble to diverse morphologies such as spherical micelles,vesicles,nanorods and wormlike-structures and possess great potential in photodynamic therapy.Particularly,porphyrin-containing alternating copolymers can be obtained by RAFT copolymerization of 4-vinylbenzylterminated tetraphenylporphyrin and maleimide isobutyl polyhedral oligomeric silsesquioxane(POSS).The steric hindrance of POSS significantly reduces theπ-πstacking of porphyrin units,which remarkably improve the singlet oxygen quantum yield and the photodynamic therapy efficacy.