文献类型：期刊文献

英文题名：Synthesis and self-assembly of a hydrophilic, thermo-responsive poly(ethylene oxide) monomethyl ether-block-poly(acrylic acid)-block-poly(N- isopropylacrylamide) copolymer to form micelles for drug delivery

作者：He, Xiaohua[1]; Wu, Xiaomeng[1]; Gao, Chunyan[1]; Wang, Kai[1]; Lin, Shaoliang[2]; Huang, Wei[1]; Xie, Meiran[1]; Yan, Deyue[1,3]

机构：[1] Department of Chemistry, East China Normal University, 3663 Zhongshan North Road, Shanghai 200062, China; [2] Key Laboratory of Advanced Polymer Materials of Shanghai, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China; [3] School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China

年份：2011

卷号：71

期号：5

起止页码：544

外文期刊名：Reactive and Functional Polymers

收录：EI(收录号：20111413895021)

语种：英文

外文关键词：Hydrophilicity - Ethylene - Controlled drug delivery - Ethers - Micelles - Carboxylic acids - Amides - Atom transfer radical polymerization - Acrylic monomers - Targeted drug delivery - Gel permeation chromatography - Hydrogels - Condensation reactions - Polyethylene oxides - Self assembly - Solutions

摘要：A hydrophilic, thermo-responsive triblock copolymer poly(ethylene oxide) monomethyl ether-block-poly(acrylic acid)-block-poly(N-isopropylacrylamide) (MPEO-b-PAA-b-PNIPAM) was synthesized by sequential atom transfer radical polymerization and hydrolysis. These polymers were characterized in detail by 1H NMR, FT-IR and gel permeation chromatography. In aqueous solution, MPEO-b-PAA-b-PNIPAM can self-assemble into core-shell-corona micelles above a LCST of the PNIPAM block. Condensation reactions easily cross-link the PAA shells, which enhances micellar stability. Doxorubicin (DOX), a model drug, was loaded into the core of the polymeric micelles and followed a pattern of thermo-sensitive drug release in vitro in cumulative release studies. Crown Copyright ? 2011 Published by Elsevier Ltd. All rights reserved.