文献类型：期刊文献

中文题名：(6,5)单壁碳纳米管对盐酸阿霉素的载药研究

英文题名：Drug Delivery System Based on(6,5)Single-Walled Carbon Nanotube Loaded with Doxorubicin Hydrochloride

作者：仲文博[1];张敏[1];章弘扬[2];王月荣[2];胡坪[2]

机构：[1]华东理工大学药学院,上海市新药设计重点实验室,上海200237;[2]华东理工大学化学与分子工程学院,上海市功能性材料化学重点实验室,上海200237

年份：2021

卷号：47

期号：1

起止页码：41

中文期刊名：华东理工大学学报（自然科学版）

外文期刊名：Journal of East China University of Science and Technology

收录：CSTPCD;;Scopus;北大核心:【北大核心2020】；CSCD:【CSCD_E2021_2022】；

基金：国家自然科学基金(81573397)。

语种：中文

中文关键词：单壁碳纳米管;盐酸阿霉素;人血清白蛋白;叶酸;靶向

外文关键词：single-walled carbon nanotubes;doxorubicin hydrochloride;human serum albumin;folic acid;targeting

摘要：以分离后的单壁碳纳米管为载药工具,制备了一种(6,5)单壁碳纳米管-盐酸阿霉素-人血清白蛋白-叶酸((6,5)SWCNT-Dox-HSA-FA)四元靶向载药系统。首先通过反应制备得到三元复合物Dox-HSA-FA,并采用双水相萃取法分离得到(6,5)SWCNT;然后采用超声作用将(6,5)SWCNT分散至Dox-HSA-FA中制备得到(6,5)SWCNT-Dox-HSA-FA;最后采用Hep G2细胞对四元复合物进行细胞毒性评价。结果表明,Dox-HSA-FA和(6,5)SWCNT-Dox-HSAFA的半数抑制浓度(IC_(50))分别为27.3μg/mL和25.7μg/mL,表明四元复合物可以提高盐酸阿霉素的靶向性。
A drug delivery system was designed in this paper.The system was composed of(6,5)chiral singlewalled carbon nanotube((6,5)SWCNT),doxorubicin hydrochloride(Dox),human serum albumin(HSA),and folic acid(FA).Firstly,the Dox-HSA-FA was prepared and(6,5)SWCNT was isolated by aqueous two-phase extraction.Then,(6,5)SWCNT-Dox-HSA-FA was dispersed into Dox-HSA-FA by ultrasonication.Finally,cytotoxicity evaluation of the complex was performed using Hep G2 cells.The results showed that the IC50 of Dox-HSA-FA and(6,5)SWCNTDox-HSA-FA was 27.3μg/mL and 25.7μg/mL,respectively.The results indicated that the targeting effect of Dox was enhanced in the(6,5)SWCNT-Dox-HSA-FA complex.