文献类型：期刊文献

英文题名：A hierarchical supramolecular nanozyme platform for programming tumor-specific PDT and catalytic therapy

作者：Huang, Baoxuan[1];Tian, Jia[1];Cui, Zepeng[1];Weng, Sihao[1];Wang, Weitao[1];Jiang, Xiaoze[2];Zhang, Weian[1]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China;[2]Donghua Univ, State Key Lab Modificat Chem Fibers & Polymer Mat, Shanghai 201620, Peoples R China

年份：2022

卷号：444

外文期刊名：CHEMICAL ENGINEERING JOURNAL

收录：;EI(收录号：20221912082069);WOS:【SCI-EXPANDED(收录号:WOS:000800390200006)】；

基金：The authors thank the financial supports by the National Natural Science Foundation of China (No. 21875063 and 51803058) , the Sci-ence and Technology Commission of Shanghai Municipality for the Shanghai International Cooperation Program (19440710600) , and the Natural Science Foundation of Shanghai (21ZR1417800) and the State Key Laboratory for Modification of Chemical Fibers and Polymer Ma-terials, Donghua University.

语种：英文

外文关键词：Supramolecular chemistry; Photodynamic therapy; Porphyrin; Nanozyme

摘要：Supramolecular chemistry as a promising tool bridges the gap between conveniently synthetic processes and multifunction through reversible noncovalent interactions. Herein, a supramolecular nanoplatform, AuP-PS, is built by flexible and reversible supramolecular interactions between pillar[5]arene-capped gold nanoparticles (AuPs) and porphyrin-containing "V " shape block copolymers (PS). The biosafety of AuP-PS was greatly improved by the formation of supramolecular complexes. Taking advantage of gradient pH changes in the tumor microenvironment (TME), AuP-PS can first disassemble into single AuP-PS nanoparticles due to the pH-sensitive DPA units of PS under pH = 6.5 and enter into the in-depth tumor sites. Whereafter, single AuP-PS nanoparticles completely dissociate, release PS and expose AuPs due to the reversible host-guest interaction at pH = 5.4, where photodynamic therapy and catalytic therapy were sufficiently activated to combat against the in-depth tumor. In vitro results indicate that the singlet oxygen yield of supramolecular AuP-PS nanoplatform was amplified 5.6 times under pH = 5.4 than that under pH = 7.4, and the nanozyme activity of AuP-PS nanoplatform was dramatically boosted 6.7 times than that of the control sample without reversible linkers under pH = 5.4. In vivo data further reveal that the supramolecular AuP-PS nanoplatform displayed superb therapeutic efficacy. Hence, this supramolecular AuP-PS nanoplatform may provide a programmed and complementary synergistic therapy strategy for in-depth and efficient treatment for solid tumors.