文献类型：期刊文献

英文题名：PIFA-Mediated Cross-Dehydrogenative Coupling of N-Heteroarenes with Cyclic Ethers: Ethanol as an Efficient Promoter

作者：Li, Xiang[1];Liu, Chaoyang[1];Guo, Shixun[1];Wang, Wei[1,2,3];Zhang, Yongqiang[1]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Sch Pharm, State Key Lab Bioengn Reactor, Shanghai 200237, Peoples R China;[2]Univ Arizona, Dept Pharmacol & Toxicol, Tucson, AZ 85721 USA;[3]Univ Arizona, BIO5 Inst, Tucson, AZ 85721 USA

年份：2021

卷号：2021

期号：3

起止页码：411

外文期刊名：EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000599074100001)，CCR-EXPANDED(收录号:WOS:000599074100001)】；

基金：Financial support from the program of the National Natural Science Foundation of China (21871086, Y.-Q. Z.; 21738002, W. W.) is gratefully acknowledged.

语种：英文

外文关键词：Cross-dehydrogenative coupling; Cyclic ethers; Ethanol; PIFA; Visible Light

摘要：Ethanol is typically used in organic synthesis as an environmentally benign solvent. Herein, we report a mild and efficient cross-dehydrogenative coupling (CDC) reaction of N-heteroarenes with cyclic ethers by uncovering the new reactivity of ethanol as an efficient promoter in PIFA-mediated radical process. The reaction proceeds smoothly under the irradiation of visible light and features excellent functional group compatibility, which allows the expedite synthesis of a variety of medicinally valuable C alpha-heteroarylated cyclic ethers in moderate to high yields.