文献类型：期刊文献

英文题名：Understanding the scale-up of fermentation processes from the viewpoint of the flow field in bioreactors and the physiological response of strains

作者：Xia, Jianye[1];Wang, Guan[1];Fan, Meng[1];Chen, Min[1];Wang, Zeyu[1];Zhuang, Yingping[1]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2021

卷号：30

起止页码：178

外文期刊名：CHINESE JOURNAL OF CHEMICAL ENGINEERING

收录：;EI(收录号：20210709930359);WOS:【SCI-EXPANDED(收录号:WOS:000651052100018)】；

基金：The authors would like to acknowledge the Projects 21776082 and 21978085 supported by National Natural Science Foundation of China, and Project 22221818014 supported by the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Fermentation; Scale-up; Bioreactors; Gas-liquid flow; Kinetics

摘要：The production capability of a fermentation process is predominately determined by individual strains, which ultimately affected ultimately by interactions between the scale-dependent flow field developed within bioreactors and the physiological response of these strains. Interpreting these complicated interactions is key for better understanding the scale-up of the fermentation process. We review these two aspects and address progress in strategies for scaling up fermentation processes. A perspective on how to incorporate the multiomics big data into the scale-up strategy is presented to improve the design and operation of industrial fermentation processes. (C) 2020 Chemical Industry and Engineering Society of China, and Chemical Industry Press Co., Ltd. All rights reserved.