文献类型：期刊文献

英文题名：Facile controlling internal structure of β-carotene-loaded protein nanoparticles by Flash Nanoprecipitation

作者：Bhutto, Rizwan Ahmed[1];Fu, Zhinan[1];Wang, Mingwei[1];Yu, Jie[1];Zhao, Fang[1];Khanal, Santosh[1];Halepoto, Adeel[1];Wang, Junyou[1];Stuart, Martien A. Cohen[1];Guo, Xuhong[1,2]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Multiphase Mat Chem Engn, Shanghai, Peoples R China;[2]Shihezi Univ, Engn Res Ctr Mat Chem Engn Xinjiang Bingtuan, Shihezi, Xinjiang, Peoples R China

年份：2021

卷号：304

外文期刊名：MATERIALS LETTERS

收录：;EI(收录号：20213110717331);WOS:【SCI-EXPANDED(收录号:WOS:000697350800010)】；

基金：We gratefully thank the financial support from the National Natural Science Foundation of China (NSFC) for Young Scholars (No. 21706074), and Key Scientific and Technological Project of Xinjiang Bingtuan (Nos. 2018AB025, 2017BTRC002).

语种：英文

外文关键词：Nanoparticle; Macrostructure; Flash Nanoprecipitation

摘要：As one of the most significant carotenoids, beta-carotene is applied widely in human nutrition and reducing incidence of chronic diseases, due to its highest provitamin A activity. The nano-carrier technology has been used to prepare beta-carotene-loaded nanoparticle to improve bioavailability in functional food and beverage, as beta-carotene is high hydrophobic. However, the control of the internal structure of beta-carotene-loaded nanoparticle is not investigated and the relationship between internal structure and release have not been well understood. Here, we report a kinetic-controlled method, Flash Nanoprecipitation, which allows to control the internal structure of beta-carotene-loaded nanoparticle, from compact core-shell structure with high packing density to loose structure with low packing density. The different structures show obviously different release behavior: loose structure associates with high release of beta-carotene, while compact structure associates with slight release. TEM and dynamic-static light scattering are employed to characterize the morphology and internal structure, respectively. The developed strategy could be helpful for practical application of beta-carotene nanoparticles with tunable properties.