文献类型：期刊文献

英文题名：A cascade approach to 3D cyclic carbamates via an ionic decarboxylative functionalization of olefinic oxamic acids

作者：Fan, Huaqiang[1,2];Wan, Yi[1,2];Pan, Peng[1,2];Cai, Wenbin[1,2];Liu, Shihui[1,2];Liu, Chuanxu[3];Zhang, Yongqiang[1,2]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioengn Reactor, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[3]Shanghai Jiao Tong Univ, Xinhua Hosp, Dept Hematol, Sch Med, Shanghai 200092, Peoples R China

年份：2020

卷号：56

期号：1

起止页码：86

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000503187300009)，CCR-EXPANDED(收录号:WOS:000503187300009)】；

基金：Financial support from the program of the National Natural Science Foundation of China (21602060, 21871086, Y.-Q. Z.; 21572055, 21738002, W. W.) and the Chinese Fundamental Research Funds for the Central Universities (ECUST: WY1714033) is gratefully acknowledged.

语种：英文

摘要：An m-CPBA-mediated intramolecular epoxidation-decarboxylative alkoxylation cascade reaction of olefinic oxamic acids has been developed. The distinct ionic decarboxylative mechanism was preliminarily revealed. The protocol features mild reaction conditions and operational simplicity, allowing the construction of diverse medicinally valuable 5-7 membered 3D cyclic carbamate architectures in moderate to high yields.