文献类型：期刊文献

英文题名：Effects of a Vibro-Tactile P300 Based Brain-Computer Interface on the Coma Recovery Scale-Revised in Patients With Disorders of Consciousness

作者：Murovec, Nensi[1,2];Heilinger, Alexander[1];Xu, Ren[2];Ortner, Rupert[3];Spataro, Rossella[1,4];La Bella, Vincenzo[5];Miao, Yangyang[6];Jin, Jing[6];Chatelle, Camille[7];Laureys, Steven[7,8];Allison, Brendan Z.[9];Guger, Christoph[1,2]

机构：[1]gtec Med Engn GmbH, Schiedlberg, Austria;[2]Guger Technol OG, Graz, Austria;[3]gtec Med Engn Spain SL, Barcelona, Spain;[4]IRCCS Ctr Neurolesi Bonino Pulejo, Palermo, Italy;[5]Univ Palermo, ALS Clin Res Ctr, BiND, Palermo, Italy;[6]East China Univ Sci & Technol, Dept Automat, Shanghai, Peoples R China;[7]Univ Liege, Coma Sci Grp, GIGA Consciousness, Liege, Belgium;[8]French Assoc Locked In Syndrome ALIS, Paris, France;[9]Univ Calif San Diego, Dept Cognit Sci, La Jolla, CA USA

年份：2020

卷号：14

外文期刊名：FRONTIERS IN NEUROSCIENCE

收录：;WOS:【SSCI(收录号:WOS:000529923700001)，SCI-EXPANDED(收录号:WOS:000529923700001)】；

基金：This research was supported by the ALS Clinical Research Center, BiND, University of Palermo, the French Association of Locked in Syndrome (ALIS), the Belgian National Fund for Scientific Research (FNRS), the European Commission (European ICT Programme Project FP7-247919 DECODER), and the University Hospital of Liege and the EC SME Phase 2 project ComAware. CC was a Marie Sklodowska-Curie fellow (H2020-MSCA-IF2016-ADOC-752686). RS is a Marie Sklodowska-Curie fellow (H2020-MSCA-IF-2018-Project number 841116).

语种：英文

外文关键词：disorders of consciousness; BCI performance; tactile stimulation; P300 event-related potential; CRS-R

摘要：Persons diagnosed with disorders of consciousness (DOC) typically suffer from motor and cognitive disabilities. Recent research has shown that non-invasive brain-computer interface (BCI) technology could help assess these patients' cognitive functions and command following abilities. 20 DOC patients participated in the study and performed 10 vibro-tactile P300 BCI sessions over 10 days with 8-12 runs each day. Vibrotactile tactors were placed on the each patient's left and right wrists and one foot. Patients were instructed, via earbuds, to concentrate and silently count vibrotactile pulses on either their left or right wrist that presented a target stimulus and to ignore the others. Changes of the BCI classification accuracy were investigated over the 10 days. In addition, the Coma Recovery Scale-Revised (CRS-R) score was measured before and after the 10 vibro-tactile P300 sessions. In the first run, 10 patients had a classification accuracy above chance level (>12.5%). In the best run, every patient reached an accuracy >= 60%. The grand average accuracy in the first session for all patients was 40%. In the best session, the grand average accuracy was 88% and the median accuracy across all sessions was 21%. The CRS-R scores compared before and after 10 VT3 sessions for all 20 patients, are showing significant improvement (p = 0.024). Twelve of the twenty patients showed an improvement of 1 to 7 points in the CRS-R score after the VT3 BCI sessions (mean: 2.6). Six patients did not show a change of the CRS-R and two patients showed a decline in the score by 1 point. Every patient achieved at least 60% accuracy at least once, which indicates successful command following. This shows the importance of repeated measures when DOC patients are assessed. The improvement of the CRS-R score after the 10 VT3 sessions is an important issue for future experiments to test the possible therapeutic applications of vibro-tactile and related BCIs with a larger patient group.