文献类型：期刊文献

英文题名：Sequence-Activated Fluorescent Nanotheranostics for Real-Time Profiling Pancreatic Cancer

作者：Tao, Yining[1];Yan, Chenxu[2,3];Li, Dan[2,3];Dai, Jianfeng[2,3];Cheng, Yingsheng[1];Li, Hui[1];Zhu, Wei-Hong[2,3];Guo, Zhiqian[2,3]

机构：[1]Shanghai Jiao Tong Univ, Dept Intervent Radiol, Shanghai 200233, Peoples R China;[2]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Key Lab Adv Mat, Inst Fine Chem,Sch Chem & Mol Engn,Shanghai Front, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Joint Int Res Lab Precis Chem & Mol Engn, Inst Fine Chem,Sch Chem & Mol Engn,Shanghai Front, Shanghai 200237, Peoples R China

年份：2022

卷号：2

期号：1

起止页码：246

外文期刊名：JACS AU

收录：EI(收录号：20225113258925);WOS:【ESCI(收录号:WOS:000772069200025)】；

基金：This work was supported by National Key Research and Development Program of China (2021YFA0910000), NSFC/China (21788102, 81571773, 81771943, 81971714, 21878087, and 21908060), Shanghai Municipal Science and Technology Major Project (Grant 2018SHZDZX03), Shanghai Municipal Education Commission (2021 Sci&Tech 03-28), and the Shuguang Program (18SG27). The patients were pathologically confirmed as pancreatic ductal adenocarcinoma at the Shanghai Jiao Tong University Affiliated Sixth People's Hospital. The written informed consent was obtained, and the protocol was approved by the Review Board of the Shanghai Jiao Tong University Affiliated Sixth People's Hospital (Approval 2021-087). The pathological specimens were immediately frozen or embedded in paraffin after being obtained.

语种：英文

外文关键词：near-infrared fluorescence; aggregation-induced emission; pancreatic ductal adenocarcinoma; sequence-activated; nanotheranostics

摘要：Pancreatic ductal adenocarcinoma (PDAC), as one of the most malignant tumors with dense desmoplastic stroma, forms a specific matrix barrier to hinder effective diagnosis and therapy. To date, a paramount challenge is in the search for intelligent nanotheranostics for such hypopermeable tumors, especially in breaking the PDAC-specific physical barrier. The unpredictable in vivo behaviors of nanotheranostics, that is, real-time tracking where, when, and how they cross the physical barriers and are taken up by tumor cells, are the major bottleneck. Herein, we elaborately design sequence-activated nanotheranostic TCM-U11&Cy@P with dual-channel near-infrared fluorescence outputs for monitoring in vivo behaviors in a sequential fashion. This nanotheranostic with a programmable targeting capability effectively breaks through the PDAC barriers. Ultimately, the released aggregation-induced emission (AIE) particle TCM-U11 directly interacts with PDAC cells and penetrates into the deep tissue. Impressively, this fluorescent nanotheranostic intraoperatively can map human clinical PDAC specimens with high resolution. We believe that this unique sequence-activated fluorescent strategy expands the repertoire of nanotheranostics in the treatment of hypopermeable tumors.