文献类型：期刊文献

英文题名：Dissociable functions of reward inference in the lateral prefrontal cortex and the striatum

作者：Tanaka, Shingo[1];Pan, Xiaochuan[1,2];Oguchi, Mineki[1];Taylor, Jessica E.[1,3];Sakagami, Masamichi[1,3]

机构：[1]Tamagawa Univ, Brain Sci Inst, Machida, Tokyo, Japan;[2]E China Univ Sci & Technol, Inst Cognit Neurodynam, Shanghai 200237, Peoples R China;[3]Tamagawa Univ, Grad Sch Brain Sci, Machida, Tokyo, Japan

年份：2015

卷号：6

外文期刊名：FRONTIERS IN PSYCHOLOGY

收录：;WOS:【SSCI(收录号:WOS:000358218700001)】；

基金：This work was supported by Grant-in-Aid for Scientific Research on Innovative Areas (4303) from MEXT (Ministry of Education, Culture, Sports, Science and Technology) of Japan (http://decisions.naist.jp/index.html) and partially supported by the Strategic Research Program for Brain Sciences from Japan Agency for Medical Research and development, AMED. XP is supported by National Natural Science Foundation of China (No. 11232005, No. 11472104) and sponsored by Shanghai Pujiang Program (No. 13PJ1402000). We thank Sanae Harada for her help on writing the manuscript.

语种：英文

外文关键词：lateral prefrontal cortex; striatum; reward inference; model-free learning; model-based learning

摘要：In a complex and uncertain world, how do we select appropriate behavior? One possibility is that we choose actions that are highly reinforced by their probabilistic consequences (model-free processing). However, we may instead plan actions prior to their actual execution by predicting their consequences (model-based processing). It has been suggested that the brain contains multiple yet distinct systems involved in reward prediction. Several studies have tried to allocate model-free and model-based systems to the striatum and the lateral prefrontal cortex (LPFC), respectively. Although there is much support for this hypothesis, recent research has revealed discrepancies. To understand the nature of the reward prediction systems in the LPFC and the striatum, a series of single-unit recording experiments were conducted. LPFC neurons were found to infer the reward associated with the stimuli even when the monkeys had not yet learned the stimulus-reward (SR) associations directly. Striatal neurons seemed to predict the reward for each stimulus only after directly experiencing the SR contingency. However, the one exception was "Exclusive Or" situations in which striatal neurons could predict the reward without direct experience. Previous single-unit studies in monkeys have reported that neurons in the LPFC encode category information, and represent reward information specific to a group of stimuli. Here, as an extension of these, we review recent evidence that a group of LPFC neurons can predict reward specific to a category of visual stimuli defined by relevant behavioral responses. We suggest that the functional difference in reward prediction between the LPFC and the striatum is that while LPFC neurons can utilize abstract code, striatal neurons can code individual associations between stimuli and reward but cannot utilize abstract code.