文献类型：期刊文献

英文题名：Engineering naphthalimide-croconaine dyes: lysosome-targeted theranostics for near-infrared photoacoustic imaging and multimodal chemodynamic/photothermal therapy

作者：Xiong, Zhixiao[1,2]; Wu, Yuxin[1]; Qiu, Shanni[1]; Xu, Yufang[1]; Zhu, Weiping[1,2]; Qian, Xuhong[1]

机构：[1] State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China; [2] Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China

年份：2025

外文期刊名：SSRN

收录：EI(收录号：20250442255)

语种：英文

外文关键词：Dyes - Infrared devices - Integration - Liposomes - Oncology - Photoacoustic effect - Theranostics - Tumors

摘要：Current cancer therapies are limited by insufficient tumor specificity and poor spatiotemporal control over therapeutic agents. These constraints impede synergistic integration of multimodal treatment approaches, compromising therapeutic efficacy while increasing systemic toxicity. Herein, naphthalimide-croconaine derivatives Cro860 and lysosome-targeted Lyso860 were synthesized by dye integration strategy, forming stable Fe2+-chelated complexes via alligator-alkaloid groups. To improve biocompatibility, we assembled LysoFNPs using liposomes. Under acidic lysosomal microenvironment (pH 4.5-5.5), the nanoparticles exhibited enhanced near-infrared (NIR) absorption, boosting photoacoustic imaging and photothermal conversion efficiency while enabling controlled Fe2+ release. In 4T1 tumor-bearing models, morpholine-modified LysoFNPs demonstrated lysosome-specific accumulation and activated concurrent photothermal therapy (PTT) and Fe2+-mediated chemodynamic therapy (CDT) under 880 nm NIR irradiation. In vivo studies confirmed tumor monitoring via photoacoustic imaging and 73.66% tumor growth suppression, highlighting their potential as multimodal theranostic agents. ? 2025, The Authors. All rights reserved.