文献类型：期刊文献

英文题名：Preparation and characterization of polydopamine and n-butyl methacrylate copolymer coatings on titanium-nickel alloy stents

作者：Liu, Yuanhui[1];Jin, Guocheng[2];Miao, Han[1];Xu, Shiai[1,3]

机构：[1]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China;[2]Shanghai Flowridge Mat Technol Co Ltd, Shanghai 201318, Peoples R China;[3]Qinghai Univ, Sch Chem Engn, Qinghai Prov Key Lab Salt Lake Mat Chem Engn, Xining 810016, Peoples R China

年份：2024

卷号：14

期号：22

起止页码：15240

外文期刊名：RSC ADVANCES

收录：;EI(收录号：20242016101534);WOS:【SCI-EXPANDED(收录号:WOS:001218106800001)】；

基金：This research is financially supported by the Shanghai Flowridge Material Technology Co. Ltd, the Young Scientists Fund of the National Natural Science Foundation of China (Grant No. 52203258), and Shanghai Pujiang Program (Grant No. 21PJ1402100).

语种：英文

外文关键词：Adhesion - Binary alloys - Block copolymers - Corrosion resistance - Corrosion resistant coatings - Diseases - Nickel alloys - Nickel coatings - Plastic coatings - Stents - Titanium alloys

摘要：Cardiovascular diseases pose a significant global health threat, and stents play a crucial role in managing these diseases. However, challenges exist with respect to the poor adhesion of stent coatings. Cardiac stents are often composed of titanium-nickel (TiNi) alloys as the metallic component and poly(n-butyl methacrylate) (PBMA) as the coating. The poor adhesion of PBMA to TiNi alloy surface may cause detachment and subsequent thrombosis post-implantation. This study utilizes Reversible Addition-Fragmentation Chain Transfer (RAFT) polymerization to synthesize a novel block copolymer, PBMA-b-PVP, composed of PBMA and poly(N-vinylpyrrolidone) (PVP). TiNi alloy surfaces are functionalized with polydopamine (PDA) to enhance polymer coating adhesion. PBMA-b-PVP exhibits a remarkable improvement in adhesion from class 5 to class 0 and high coating stability after a 15 days immersion in a phosphate buffer solution. The corrosion current density is reduced by 44% with the incorporation of PDA into PBMA-b-PVP coatings, suggesting high corrosion resistance. PDA-functionalized coatings promote cell viability without cytotoxicity, suggesting high biocompatibility. This study provides a robust strategy for preparing stent coatings with high adhesion, corrosion resistance, and biocompatibility.