文献类型：期刊文献

英文题名：Tuning the Solid- and Solution-State Fluorescence of the Iron-Chelator Deferasirox

作者：Hu, Xi-Le[1,2];Sedgwick, Adam C.[3,4];Mangel, Daniel N.[3];Shang, Ying[1,2];Steinbrueck, Axel[3];Yan, Kai-Cheng[1,2];Zhu, Ling[1,2];Snelson, Dylan W.[3];Sen, Sajal[3];Chau, Calvin, V[3];Juarez, Gabriel[3];Lynch, Vincent M.[3];He, Xiao-Peng[1,2];Sessler, Jonathan L.[3]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Joint Int Res Lab Precis Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr,Front, Shanghai 200237, Peoples R China;[3]Univ Texas Austin, Dept Chem, Austin, TX 78712 USA;[4]Univ Oxford, Chem Res Lab, Oxford OX1 3TA, England

年份：2022

卷号：144

期号：16

起止页码：7382

外文期刊名：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

收录：;EI(收录号：20221712025851);WOS:【SCI-EXPANDED(收录号:WOS:000799141600041)】；

基金：The authors thank the National Natural Science Foundation of China (nos. 21788102, 91853201, and 21907030), the Shanghai Municipal Science and Technology Major Project (no. 2018SHZDZX03), the International Cooperation Program of Shanghai Science and Technology Committee (no. 19410712600), and the Fundamental Research Funds for the Central Universities (222201717003) for financial support. The work in Austin was supported by the Robert A. Welch Foundation (F-0018). The authors acknowledge the Texas Advanced Computer Center (TACC) at The University of Texas at Austin for providing HPC resources that have contributed to the research results reported in this paper. A.C.S. would like to thank the Glasstone Research fellowship (University of Oxford) and Jesus College, Oxford for their support.

语种：英文

外文关键词：Bacteria - Iron - Chelation - Fluorescence - Solid solutions - Stimulated emission

摘要：Deferasirox, an FDA-approved iron chelator, has gained increasing attention for use in anticancer and antimicrobial applications. Recent efforts by our group led to the identification of this core as an easy-to-visualize aggregation-induced emission platform, or AIEgen, that provides a therapeutic effect equivalent to deferasirox (J. Am. Chem. Soc. 2021, 143, 3, 1278-1283). However, the emission wavelength of the first-generation system overlapped with that of Syto9, a green emissive dye used to indicate live cells. Here, we report a library of deferasirox derivatives with various fluorescence emission profiles designed to overcome this limitation. We propose referring to systems that show promise as both therapeutic and optical imaging agents as "illuminoceuticals". The color differences between the derivatives were observable to the unaided eye (solid- and solution-state) and were in accord with the Commission Internationale de L'Eclairage (CIE) chromaticity diagram 1913. Each fluorescent derivative successfully imaged the respective spherical and rod shapes of methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. They also displayed iron-dependent antibiotic activity. Three derivatives, ExNMe(2) (3), ExTrisT (11), and ExDCM (13), display emission features that are sufficiently distinct so as to permit the multiplex (triplex) imaging of both MRSA and P. aeruginosa via stimulated emission depletion microscopy. The present deferasirox derivatives allowed for the construction of a multi-fluorophore sensor array. This array enabled the successful discrimination between Gram-positive/Gram-negative and drug-sensitive/drug-resistant bacteria. Antibiotic sensitivity and drug-resistant mutants from clinically isolated strains could also be identified and differentiated.