文献类型：期刊文献

中文题名：Construction of 3-Azabicyclo[3.1.0]hexane Backbone by the Reaction of Allenes with Allylamines via Tandem Michael Addition and Copper-Mediated Oxidative Carbanion Cyclization

作者：Hui Xu[1];Teng Han[1];Xiaoyan Luo[1];Wei-Ping Deng[1]

机构：[1]Shanghai Key Laboratory of New Drug Design and School of Pharmacy,East China University of Science and Technology,130 Meilong Road,Shanghai 200237,China

年份：2021

卷号：39

期号：3

起止页码：666

中文期刊名：Chinese Journal of Chemistry

外文期刊名：中国化学（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2021_2022】；

基金：the Shanghai Comittee of Science and Technology(No.17ZR1407600)。

语种：英文

中文关键词：Oxidative coupling;Allenes;Allylamine;3-Azabicyclo[3,1,0]hexane;Miachel addition

摘要：Main observation and conclusion A facile synthetic method for the construction of 3-azabicyclo[3.1.0]hexane in the presence of copper catalyst system was developed.The reaction proceeds through Michael addition of allylamines with allenes followed by copper-mediated intramolecular oxidative carbanion 5-exo-trig radical cyclization,affording potential biologically active 3-azabicyclo[3.1.O]hexane derivatives in moderate to high yields(42%-85%).