文献类型：会议论文

英文题名：Stem Cell Growth and Migration on Nanofibrous Polymer Scaffolds and Micro-Fluidic Channels on Silicon-Chip

作者：Liu, Johan[1,3];Kuhn, H. Georg[2];Jing, Yujia[1,4];Dahlberg, Jan-Olof[1];Ericsson, Linnea[1];Nilsson, Anna[1];Nyberg, Lena[1];Ohady, Behroz[1];Svensson, Johan[1];Carlberg, Bjorn[1];Cooper-Kuhn, Christiana M.[2];Wang, Teng[1];Zhu, Yihua[4]

机构：[1]Chalmers Univ Technol, BioNano Syst Lab, Dept Microtechnol & Nanosci, SE-41296 Gothenburg, Sweden;[2]Univ Gothenburg, Inst Neurosci & Physiol, Ctr Brain Repair & Rehabilitat, Gothenburg, Sweden;[3]Shanghai Univ, Sch Mech Engn & Automat, Key Lab New Displays & Syst Appl & SMIT Ctr, Shanghai 200072, Peoples R China;[4]East China Univ Sci & Technol, Dept Mat Sci & Engn, Key Lab Ultrafine Mat Ministry Edu, Shanghai, Peoples R China

会议论文集：59th Electronic Components and Technology Conference

会议日期：MAY 26-29, 2009

会议地点：San Diego, CA

语种：英文

外文关键词：Scaffolds (biology) - Growth kinetics - Silicon - Cell culture - Nanofibers - Cell growth - Lithography

摘要：Stem cell growth and migration on nanofibrous scaffolds and micro-fluidic channels on Silicon-Chip were studied by using neural stem cells isolated from adult rats' brain. Electrospinning and lithographic technique were used for developing nanofibrous-polylactic acid (PLA) and polyurethane (PU) based-scaffolds and micro-fluidic channels on Si-Chips respectively. Immunocytochemical and morphological analysis showed better cell-matrix interaction with profound adhesion, proliferation and migration on the developed scaffolds. Cell culture assay with microfluidic channel revealed the ability of developed channel system in guiding neuronal stem cell growth towards specified directions. These studies extend the possibility of using developed nanofibrous scaffolds and micro-fluidic channel system for future electrical signal transmission based on living neural stem cells.