文献类型：期刊文献

英文题名：Diastereo- and Enantioselective Organocatalytic Direct Conjugate Addition of γ-Butenolide to Chalcones

作者：Zhang, Yinan[2];Yu, Chenguang[2];Ji, Yafei[1];Wang, Wei[1,2,3]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[2]Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA;[3]Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

年份：2010

卷号：5

期号：6

起止页码：1303

外文期刊名：CHEMISTRY-AN ASIAN JOURNAL

收录：;EI(收录号：20102212978055);WOS:【SCI-EXPANDED(收录号:WOS:000278840200006)】；

基金：Financial support for this work provided by the NSF (CHE-0704015) is gratefully acknowledged. Thanks are expressed to Dr. Elieen N. Duesler for performing X-ray analysis. The Bruker X8 X-ray diffractometer was purchased via an NSF CRIF:MU award to the University of New Mexico, CHE-0443580.

语种：英文

外文关键词：enones; lactones; Michael addition; organocatalysis; thioureas

摘要：A diastereo- and enantioselective conjugate addition reaction of γ-butenolide with chalcones has been developed. Notably, unmodified γ-butenolide was directly employed as a nucleophile in the Michael addition reactions. This process was catalyzed by a previously reported cyclohexane diamine thiourea under mild reaction conditions to afford enantioenriched synthetically and biologically important substituted furanones. ? 2010 Wiley-VCH Verlag GmbH&Co. KGaA, Weinheim.