文献类型：期刊文献

中文题名：高尿酸血症与痛风研究进展

英文题名：Advances in the study of hyperuricemia and gout

作者：梁晓萍[1,2];梁琼麟[2];胡坪[1];罗国安[1,2];王义明[2]

机构：[1]华东理工大学中药现代化工程中心,上海200237;[2]清华大学生命科学与医学研究院,北京100084

年份：2008

卷号：24

期号：10

起止页码：1265

中文期刊名：中国药理学通报

外文期刊名：Chinese Pharmacological Bulletin

收录：CSTPCD;;Scopus;北大核心:【北大核心2004】；CSCD:【CSCD2011_2012】；

基金：国家重点基础研究发展计划(973计划)资助项目(No2007CB511903);国家自然科学基金资助项目(No90709045);国家“十一五”科技支撑计划资助项目(No2006BAI08B04-01)

语种：中文

中文关键词：痛风;高尿酸血症;嘌呤代谢紊乱;遗传性因素

外文关键词：gout; hyperuricemia; purine metabolic disorder; genetic factors

摘要：高尿酸血症和痛风的发生是遗传和环境因素相互作用的结果,其中遗传性因素近年来尤其得到广泛的关注。导致高尿酸血症和痛风的主要遗传性因素包括嘌呤代谢过程中关键酶的缺乏、遗传性肾脏功能障碍和其他遗传代谢病。该文主要从以上3方面对遗传性因素导致的高尿酸血症及痛风的研究进展进行综述,并对该疾病研究的发展趋势进行展望。
The occurrence of hyperuricemia and gout is induced by the interaction of genetic and environmental factors, and the former one is especially concerned in recent years. Studies suggested that several factors, which mainly consisted of the deficiency of pivotal enzymes involved in purine metabolism, mutations in kidney and other genetic metabolic diseases, contribute to the aceurence of hyperuricemia and gout. In this paper,recent advance in the study of hereditary factors of hyperuricemia and gout is reviewed and the trend of diagnosis and prevention for hyperuricemia and gout is also prospected.