文献类型：期刊文献

英文题名：Thermo-Bistable Red and Sensitized Near-Infrared Photoswitches

作者：Zhang, Zhiwei[1];Hu, Zhubin[2];Huang, Lei[1];Guo, Huichao[1];Dai, Jinghong[1];Deng, Long[1];Gong, Guining[1];Xia, Tong[1];Sun, Ruijia[3];Ji, Botao[3];Zhu, Wei-Hong[1];Zhang, Junji[1];Tian, He[1]

机构：[1]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn, Key Lab Adv Mat & Joint Int Res Lab Precis Chem &, Shanghai 200237, Peoples R China;[2]East China Normal Univ, Sch Phys, State Key Lab Precis Spect, Shanghai 200241, Peoples R China;[3]Westlake Univ, Sch Engn, Zhejiang Key Lab 3D Micro Nano Fabricat & Characte, Hangzhou 310030, Peoples R China

年份：2026

卷号：148

期号：6

起止页码：6474

外文期刊名：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

收录：;EI(收录号：20260820134811);WOS:【SCI-EXPANDED(收录号:WOS:001683956500001)】；

基金：This work is supported by the Basic Science Center of the National Natural Science Foundation (T2488302), the National Natural Science Foundation of China (22122803, 22378121, 92356301, 22338006, 22478118, and 22101084), Science and Technology Commission of Shanghai Municipality (24DX1400200), and the Fundamental Research Funds for the Central Universities (222201717003). J.Z. acknowledges Shanghai Natural Science Foundation Project (23ZR1479500 and 23JC1401700). Z.Z. acknowledges the Young Elite Scientists Sponsorship Program (2023) by the Chinese Chemical Society (CCS). The authors wish to acknowledge Youjun Yang and Yuyang Zhang for their help in the imaging of cell membranes.

语种：英文

外文关键词：Biological materials - Biological systems - Functional materials - Isomers - Optoelectronic devices - Photochromism - Photoisomerization - Quantum efficiency - Thermal Engineering

摘要：Molecular photoswitching in the red and near-infrared (NIR) region is highly sought after for applications in biological systems, optoelectronic devices, and functional materials where low-energy light minimizes photodamage and enables deep-tissue penetration. However, developing photoswitches that simultaneously achieve long-wavelength responsiveness with robust thermal bistability and high quantum efficiency remains a formidable challenge. Here, we report an intrinsic thermo-bistable, red-light-responsive (605 nm/730 nm) photochromic motif based on a perylene bisimide (PBI) scaffold, which further enables an unprecedented sensitized NIR (808 nm/730 nm) photoisomerization through a triplet pathway. Rational side-chain engineering with aryl substituents of distinct aromaticity and electronic character finely tunes the transition-state energy barrier (Delta G double dagger = 45.07 kcal mol-1), leading to exceptional thermal stability and a long-lived closed isomer. Further molecular engineering of PBI-based photoswitches also delivers high photoisomerization quantum yield, bright fluorescence, and near-quantitative photoconversion efficiency. This work provides a new photochromic motif that boosts the overall photochemical/thermal performances of molecular photoswitching at the red-light end, thereby enriching the structural and functional landscape of a high-performance photoswitching system. Demonstrations in dynamic cell-membrane imaging further highlight the potential of these PBI-based photoswitches as powerful photochemical platforms for advanced biomedical and optoelectronic applications.