文献类型：期刊文献

英文题名：Advances in Biosynthesis of Natural Products from Marine Microorganisms

作者：Zhou, Quan[1];Hotta, Kinya[2];Deng, Yaming[1];Yuan, Rui[1];Quan, Shu[3];Chen, Xi[1]

机构：[1]Northwest Univ, Coll Chem & Mat Sci, Key Lab Synthet & Nat Funct Mol, Minist Educ, Xian 710127, Peoples R China;[2]Genetech Biotechnol Pte Ltd, 8 Temasek Blvd 34-03, Singapore 038988, Singapore;[3]East China Univ Sci & Technol, Shanghai Collaborat Innovat Ctr Biomfg, State Key Lab Bioreactor Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2021

卷号：9

期号：12

外文期刊名：MICROORGANISMS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000735495400001)】；

语种：英文

外文关键词：marine natural products; genomic screening; heterologous expression; combinatorial biosynthesis

摘要：Natural products play an important role in drug development, among which marine natural products are an underexplored resource. This review summarizes recent developments in marine natural product research, with an emphasis on compound discovery and production methods. Traditionally, novel compounds with useful biological activities have been identified through the chromatographic separation of crude extracts. New genome sequencing and bioinformatics technologies have enabled the identification of natural product biosynthetic gene clusters in marine microbes that are difficult to culture. Subsequently, heterologous expression and combinatorial biosynthesis have been used to produce natural products and their analogs. This review examines recent examples of such new strategies and technologies for the development of marine natural products.