文献类型：期刊文献

英文题名：Phosphine-Catalyzed Aza-MBH Reactions of Vinylpyridines: Efficient and Rapid Access to 2,3,5-Triarylsubstituted 3-Pyrrolines

作者：Chen, Jing[1];Li, Jianjun[2];Wang, Jiazhe[2];Li, Hao[2];Wang, Wei[2,3];Guo, Yuewei[1]

机构：[1]Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China;[2]E China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Sch Pharm, Shanghai 200237, Peoples R China;[3]Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA

年份：2015

卷号：17

期号：9

起止页码：2214

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000354004400045)，CCR-EXPANDED(收录号:WOS:000354004400045)】；

基金：This research was financially supported by the National Marine "863" Projects (No. 2013AA092902), NSFC-Shangdong Joint Fund for Marine Science Research Centers (Grant No. U1406402), the program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning (No. 201226), the National Science Foundation of China (No. 21372073), and East China University of Science and Technology.

语种：英文

摘要：Vinylpyridines have been developed in,aza-Morita-Baylis-Hiliman (MBH) reaction to construct triarylsubstituted 3-pyrrolines. The first electron deficient,aromatic ring is marked as an activating mode for the vinyl group in the MBH reaction. This method provides efficient and rapid access to a range of triarylpyrrolines in good yields and at an excellent level of diastereoselectivity. Moreover, the synthetic potential of this protocol is further enhanced by the straightforward synthesis of unsymmetrical tri- and polyarylsubstituted pyrroles.