文献类型：期刊文献

英文题名：Coupling effects of human serum albumin and sodium chloride on biological desiccation patterns

作者：Wang, Jihong[1,2];Zhang, Min[1,2,3];Wang, Jun[1,2,3];Chen, Ruoyang[1,2,3]

机构：[1]East China Univ Sci & Technol, Sch Phys, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China;[3]Univ Chinese Acad Sci, Wenzhou Inst, Zhejiang 325000, Peoples R China

年份：2023

卷号：9

期号：9

外文期刊名：HELIYON

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001140567700001)】；

基金：We acknowledge financial support by the National Natural Science Foundation of China under Grant No. 12205101.

语种：英文

外文关键词：Desiccation; Cracking pattern; Crystal pattern; Bio-fluid

摘要：Desiccation patterns of plasma sessile drops have attracted increasing attention, not only because of the fantastic underlying physics, but also due to their potential of being health diagnostic tools. However, plasma is a multicomponent system, which contains macromolecular proteins and inorganic salts; these components have complicated interactions to define pattern morphologies. Unfortunately, mechanisms of coupling effects of main components on pattern morphologies are still not clear, thus limiting their diagnostic applications. Here we show the coupling effects of human serum albumin (HSA) and sodium chloride (NaCl) on plasma desiccation patterns. Our experiments indicate that NaCl enhances the "coffee ring" effect of HSA to promote its aggregation at the peripheral region and narrows down its aggregation area; this would influence the distribution of internal stresses, resulting in a larger number of radial cracks, with a larger width but a shorter length, than cracks in pure HSA. In the meantime, HSA experiences the gelation process that propagates from the peripheral region to central region and causes the spatiotemporal deviation in the degree of solidification, which induces a higher concentration of NaCl in the central region, thus leading to the formation of crystal patterns. Our further experiments demonstrate that these characteristic patterns are correlated to the variation in the concentration of NaCl, which can be caused by hyponatremia and hypernatremia in real biofluids. Our findings not only provide a new mechanistic insight into biological desiccation patterns, but also bridge the gap between the understanding and diagnostic applications of these desiccation patterns.