文献类型：期刊文献

英文题名：Metal- and Base-Free Direct N-Arylation of Pyridazinones by Using Diaryliodonium Salts: An Anion Effect

作者：Xu, Bowen[1];Han, Jianwei[1,2];Wang, Limin[1]

机构：[1]East China Univ Sci & Technol, Inst Fine Chem, Sch Chem & Mol Engn, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai Hong Kong Joint Lab Chem Synth, 345 Lingling Rd, Shanghai 200032, Peoples R China

年份：2018

卷号：7

期号：8

起止页码：1674

外文期刊名：ASIAN JOURNAL OF ORGANIC CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000441415100029)，CCR-EXPANDED(收录号:WOS:000441415100029)】；

基金：The work was supported by the National Nature Science Foundation of China (NSFC 21472213, 21772039), National Key Program (2016YFA0200302, Study on application and preparation of aroma nanocomposites), the Fundamental Research Funds for the Central Universities and Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences.

语种：英文

外文关键词：anions; arylation; diaryliodonium salts; radical reactions

摘要：An efficient N-arylation of pyridazinones with diaryliodonium salts has been developed without using base or metal catalysts. The reaction tolerated a variety of both diaryliodonium salts and pyridazinone derivatives with diverse functional groups. Furthermore, a drug candidate for treatment of neuropathic pain was synthesized with this procedure in good yield.