文献类型：期刊文献

中文题名：Near-infrared fluorescent probes for imaging of amyloid plaques in Alzheimer's disease

英文题名：Near-infrared fluorescent probes for imaging of amyloid plaques in Alzheimer's disease

作者：Hongjuan Tong[1];Kaiyan Lou[1];Wei Wang[1,2]

机构：[1]Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, State Key Laboratory of Bioengineering Reactor,East China University of Science and Technology;[2]Department of Chemistry and Chemical Biology, University of New Mexico

年份：2015

卷号：5

期号：1

起止页码：25

中文期刊名：Acta Pharmaceutica Sinica B

外文期刊名：药学学报（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2015_2016】；PubMed;

基金：supported by the Fundamental Research Funds for the Central Universities and East China University of Science and Technology (start-up funds, Wei Wang);the China 111 Project (Grant B07023, Wei Wang)

语种：英文

中文关键词：Alzheimer’s disease;Blood-brain barrier;Fluorescence probe;Near-infrared fluorescence;Optical imaging;Amyloid-β plagues

外文关键词：Alzheimer's disease;;Blood-brain barrier;;Fluorescence probe;;Near-infrared fluorescence;;Optical imaging;;Amyloid-β plagues

摘要：One of the early pathological hallmarks of Alzheimer's disease(AD) is the deposition of amyloid-β(Aβ) plaques in the brain. There has been a tremendous interest in the development of Aβ plaques imaging probes for early diagnosis of AD in the past decades. Optical imaging, particularly near-infrared fluorescence(NIRF) imaging, has emerged as a safe, low cost, real-time, and widely available technique, providing an attractive approach for in vivo detection of Aβ plaques among many different imaging techniques. In this review,we provide a brief overview of the state-of-the-art development of NIRF Aβ probes and their in vitro and in vivo applications with special focus on design strategies and optical, binding, and brain-kinetic properties.
One of the early pathological hallmarks of Alzheimer's disease(AD) is the deposition of amyloid-β(Aβ) plaques in the brain. There has been a tremendous interest in the development of Aβ plaques imaging probes for early diagnosis of AD in the past decades. Optical imaging, particularly near-infrared fluorescence(NIRF) imaging, has emerged as a safe, low cost, real-time, and widely available technique, providing an attractive approach for in vivo detection of Aβ plaques among many different imaging techniques. In this review,we provide a brief overview of the state-of-the-art development of NIRF Aβ probes and their in vitro and in vivo applications with special focus on design strategies and optical, binding, and brain-kinetic properties.