文献类型：期刊文献

英文题名：Ordered-Pore-Structure Engineering of Dual-Emissive Lanthanide-Based Metal-Organic Frameworks for Boosting Sensing Performance of Tumor Marker

作者：Li, Wen[1];Ge, Kaiming[1];Hao, Ji-Na[1];Li, Yongsheng[1]

机构：[1]East China Univ Sci & Technol, Frontier Sci Ctr Mat Biol & Dynam Chem, Shanghai Engn Res Ctr Hierarch Nanomat,Lab Low Dim, Sch Mat Sci & Engn,Key Lab Ultrafine Mat,Minist Ed, Shanghai 200237, Peoples R China

年份：2025

卷号：97

期号：47

起止页码：25979

外文期刊名：ANALYTICAL CHEMISTRY

收录：;EI(收录号：20254919643114);WOS:【SCI-EXPANDED(收录号:WOS:001619508000001)】；

基金：This work was financially supported by the National Key Research and Development Program of China (2024YFF0508601), the National Natural Science Foundation of China (52172279, 52572302, and 52572303), Leading Talents in Shanghai in 2018, and the Higher Education Discipline Innovation Project (B14018).

语种：英文

外文关键词：Crystalline materials - Diagnosis - Diseases - Mesopores - Micropores - Microporosity - Organometallics - Pore structure - Probes - Reliability analysis - Screening

摘要：Accurate identification of tumor metabolic markers is of great significance for the early screening of cancer. Luminescent lanthanide-based metal-organic frameworks (Ln-MOFs) are a fascinating assay platform for biomarkers, but the influence of their pore parameters on detection performance remains largely unexplored due to the lack of Ln-MOFs with an adjustable micro- and mesoporous structure. Herein, two isoreticular dual-emissive Ln-MOF-based sensors with microporous and hierarchically micromesoporous structures, namely, Eu-MMOF-BTC and Eu-HMMOF-BTC, respectively, are first constructed to systematically investigate their detection properties for adenosine (ADO, an important tumor marker in the diagnosis and prognosis of cancer). Remarkably, compared with the Eu-MMOF-BTC with micropores only, the Eu-HMMOF-BTC featuring both intrinsic micropores and large ordered mesopores affords greatly enhanced photoresponse efficiency and sensitivity toward ADO under both signal channels, benefiting from the facilitated access to active sites and improved preconcentration. Moreover, such an optimized dual-channel Eu-HMMOF-BTC sensor realizes real-time (15 s) and specific recognition of ADO in a complex urine environment without the interference of coexisting species, inherently improving the analysis reliability and accuracy. This study not only provides a facile strategy to regulate the sensing performance of MOF-based probes by ordered-pore-structure engineering but also provides inspiration for the design of high-accuracy probes for the noninvasive early screening of cancers.