文献类型：期刊文献

英文题名：Chitosan cross-linked poly(acrylic acid) hydrogels: Drug release control and mechanism

作者：Wang, Yiming[1,2];Wang, Jie[1];Yuan, Zhenyu[1];Han, Haoya[1,3];Li, Tao[1];Li, Li[1];Guo, Xuhong[1,4]

机构：[1]East China Univ Sci & Technol, State Key Lab Chem Engn, Meilong Rd 130, Shanghai 200237, Peoples R China;[2]Delft Univ Technol, Dept Chem Engn, Adv Soft Matter Grp, NL-2629 HZ Delft, Netherlands;[3]Tech Univ Berlin, Stranski Lab Phys & Theoret Chem, Str 17 Juni 124, D-10623 Berlin, Germany;[4]Shihezi Univ, Engn Res Ctr Mat Chem Engn Xinjiang Bingtuan, Xinjiang 832000, Peoples R China

年份：2017

卷号：152

起止页码：252

外文期刊名：COLLOIDS AND SURFACES B-BIOINTERFACES

收录：;EI(收录号：20170403275954);WOS:【SCI-EXPANDED(收录号:WOS:000398014100030)】；

基金：We gratefully acknowledge NSFC Grants (51403062, 21476143 and 51273063), the China Scholarship Council (CSC), China Postdoctoral Science Foundation (2013M541485), 111 Project Grant (B08021), the Fundamental Research Funds for the Central Universities and the Open Project of Engineering Research Center of Materials-Oriented Chemical Engineering of Xinjiang Bingtuan (2015BTRC001) for support of this work.

语种：英文

外文关键词：Chitosan; pH sensitive hydrogel; Drug delivery; Release mechanism

摘要：Chitosan has been used to cross-link poly(acrylic acid) to give three pH-sensitive hydrogels designed to control the release of the drugs amoxicillin and meloxicam. The extent of cross-linking and solution pH was found to dominate the swelling behavior of these hydrogels as shown by scanning electron microscopy and swelling time dependencies. The rates of release of amoxicillin and meloxicam from the loaded hydrogels increased with increase in pH consistent with the extent of hydrogen bonding between hydrogel components and between the hydrogel and the drugs being important determinants of release rate. Both the Korsemeyer-Peppas and Weibull models fitted release data consistent with drug release occurred through a combination of drug diffusion and hydrogel relaxation processes. These hydrogels appear to provide an ideal basis for controlled drug delivery systems. (C) 2017 Elsevier B.V. All rights reserved.