文献类型：期刊文献

中文题名：Synthesis and self-assembly of poly(ethylene glycol)-block-poly(N-3-(methylthio)propyl glycine)and their oxidation-sensitive polymersomes

作者：Yangwei Deng[1,2];Hui Chen[1];Xinfeng Tao[1,5];Sylvain Trepout[4];Jun Ling[2];Min-Hui Li[1,3]

机构：[1]Chimie ParisTech,PSL University Paris,CNRS,Institut de Recherche de Chimie Paris,Paris 75005,France;[2]MOE Key Laboratory of Macromolecular Synthesis and Functionalization,Department of Polymer Science and Engineering,Zhejiang University,Hangzhou 310027,China;[3]Beijing Advanced Innovation Center for Soft Matter Science and Engineering,Beijing University of Chemical Technology,Beijing 100029,China;[4]Institut Curie,Inserm US43,University Paris Saclay,Orsay Cedex 91405,France;[5]Shanghai Key Laboratory of Advanced Polymeric Materials,School of Materials Science and Engineering,East China University of Science and Technology,Shanghai 200237,China

年份：2020

卷号：31

期号：7

起止页码：1931

中文期刊名：Chinese Chemical Letters

外文期刊名：中国化学快报（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2019_2020】；PubMed;

基金：the French National Research Agency(No.ANR16-CE29-0028);the National Natural Science Foundation of China(No.21674091);the Joint Foundation of Shaanxi Province Natural Science Basic Research Program;Shaanxi Coal Chemical Group Co.,Ltd.(No.2019JLM-46)for financial support;the China Scholarship Council for funding his Ph.D.scholarship in France。

语种：英文

中文关键词：Polypeptoid;Self-assembly;Polymersome;Oxidation-responsive;Glucose oxidase

摘要：Amphiphilic block copolymers poly(ethylene glycol)-block-poly(N-3-(methylthio)propyl glycine)(PEGb-PMeSPG)were synthesized via ring-opening polymerization of N-3-(methylthio)propyl glycine Nthiocarboxyanhydride(MeSPG-NTA)initiated by amino-terminated PEG.The self-assemblies of three PEG-b-PMeSPG copolymers with different PMeSPG block lengths were first prepared by nanoprecipitation method using THF and DMF,respectively,as the organic solvent,and their morphologies were studied by Cryo-EM and DLS.To prepare polymersomes loaded with glucose oxidase(GOx),double emulsion method followed by extrusion treatment was employed.The oxidation-responsive disruption of polymersomes was achieved upon the introduction of glucose because of the oxidants generated insitu by GOx/glucose.